TY - JOUR AU - Nedel, Wagner; Lisboa, Thiago; Salluh, Jorge I.F. TI - What Is the Role of Steroids for Septic Shock in 2021? SN - 1069-3424 SN - 1098-9048 PY - 2021 JO - Semin Respir Crit Care Med JF - Seminars in Respiratory and Critical Care Medicine LA - EN VL - 42 IS - 05 SP - 726 EP - 734 DA - 2021/09/20 KW - septic shock KW - corticosteroids KW - clinical trials AB - Corticosteroids have been used for decades in the adjunctive treatment of severe infections in intensive care. The most frequent scenario in intensive care is in septic shock, where low doses of glucocorticoids appear to restore vascular responsiveness to norepinephrine. There is a strong body of evidence suggesting that hydrocortisone reduces time on vasopressor, and may modulate the immune response. In this review, we explore the current evidence supporting the use of corticosteroids in septic shock, its benefits, and potential harms. In addition to landmark clinical trials, we will also describe new frontiers for the use of corticosteroids in septic shock which should be explored in future studies. PB - Thieme Medical Publishers, Inc. DO - 10.1055/s-0041-1733900 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0041-1733900 ER -