TY - JOUR AU - Kim, Byungjun; Kim, Yongjae; Lee, Sarah Yunmi TI - Stereoselective Michael Additions of Arylacetic Acid Derivatives by Asymmetric Organocatalysis SN - 0936-5214 SN - 1437-2096 PY - 2022 JO - Synlett JF - Synlett LA - EN VL - 33 IS - 07 SP - 609 EP - 616 DA - 2022/01/05 KW - asymmetric catalysis KW - organocatalysis KW - Michael addition KW - iminium catalysis KW - isothiourea catalysis KW - synergistic catalysis AB - Because of the versatility of chiral 1,5-dicarbonyl structural motifs, the development of stereoselective Michael additions of arylacetic acid derivatives to electron-deficient alkenes is an important challenge. Over recent decades, an array of enantio- and diastereoselective methods of this type have been developed through the use of chiral organocatalysts. In this article, three distinct strategies in this research area are highlighted. Catalytic generation of either a chiral iminium electrophile (iminium catalysis) or a chiral enolate nucleophile (Lewis­ base catalysis) has allowed the efficient construction of stereogenic C–C bonds. We also introduce a synergistic catalytic approach involving the merger of these two catalytic cycles that provides selective access to all four stereoisomers of products with vicinal stereocenters.1 Introduction2 Iminium Catalysis3 Lewis Base Catalysis4 Synergistic Organocatalysis5 Summary PB - Georg Thieme Verlag KG DO - 10.1055/s-0041-1737323 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0041-1737323 ER -