TY - JOUR AU - Kumar, Manjeet; Barwal, Kailash Chander; Sharma, Sunish; Chauhan, Sanjeev; Raina, Pamposh TI - Granulomatosis with Polyangiitis Presenting as a Renal Mass: A Scarce Case Report with a Review of the Literature SN - 0379-038X SN - 2454-5635 PY - 2023 JO - Ann Natl Acad Med Sci JF - Annals of the National Academy of Medical Sciences (India) LA - EN VL - 59 IS - 01 SP - 055 EP - 059 DA - 2023/02/16 KW - Wegener granulomatosis KW - granulomatosis with polyangiitis KW - immunosuppressive therapy AB - Wegener granulomatosis (WG) now known as granulomatosis with polyangiitis (GPA) is an uncommon autoimmune disorder of undivulged etiology affecting the respiratory tract including paranasal sinuses, nasal cavity, lungs, and kidneys predominantly. GPA presenting as a solitary renal mass is rarely seen. We present a case report of a 27-year-old female presenting with a right renal mass along with pain, low-grade fever, and arthralgia. Computed tomography scan of the abdomen revealed a hypodense low attenuated renal mass with indistinct margins. Ultrasound-guided biopsy revealed features typical of GPA. She was started on oral steroids (prednisolone 40 mg) and azathioprine. She developed pain, vomiting, and diarrhea after starting treatment with azathioprine. Azathioprine was stopped and rituximab 1 g weekly was started for 4 weeks followed by 500 mg 6 monthly injections. She got symptomatic relief at 4 weeks with a diminution of renal mass at 6 months follow-up. We report this rare entity of WG presenting as renal mass. Suspecting and diagnosing renal mass as a part of GPA prevented us from undertaking unnecessary surgical treatment in this patient. Medical treatment with steroids and rituximab is effective in inducing remission and maintenance. PB - Thieme Medical and Scientific Publishers Pvt. Ltd. DO - 10.1055/s-0042-1760352 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0042-1760352 ER -