Leptin activates PI3-kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. - Kellerer,M.; Koch,M.; Metzingher,E.; Mushack,J.; Capp,E.; Haring,H.U. (Diabetologia, 1997)