Antiestrogens. 2. Structure-activity studies in a series of 3-aroyl-2-arylbenzo[b]thiophene derivatives leading to [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3- yl] [4-[2-(1-piperidinyl)ethoxy]-phenyl]methanone hydrochloride (LY156758), a remarkably effective estrogen antagonist with only minimal intrinsic estrogenicity. - Jones,C.D.; Jevnikar,M.G.; Pike,A.J.; Peters,M.K.; Black,L.J.; Thompson,A.R. (J Med Chem, 1984)