Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension. - Barroso,I.; Gurnell,M.; Crowley,V.E.; Agostini,M.; Schwabe,J.W.; Soos,M.A.; Maslen,G.L.; Williams,T.D.; Lewis,H.; Schafer,A.J.; Chatterjee,V.K.; O'Rahilly,S. (Nature, 1999)