High-dose growth hormone (GH) treatment in non-GH-deficient children born small for gestational age induces growth responses related to pretreatment GH secretion and associated with a reversible decrease in insulin sensitivity. - De Zegher,F.; Ong,K.; Helvoirt,M van.; Mohn,A.; Woods,K.; Dunger,D. (J Clin Endocrinol Metab, 2002)