Systemic levels contribute significantly to increased intraocular IGF-I, IGF-II and IGF-BP3 in proliferative diabetic retinopathy. - Spranger,J.; Buhnen,J.; Jansen,V.; Krieg,M.; Meyer-Schwickerath,R.; Blum,W.F.; Schatz,H.; Pfeiffer,A.F. (Horm Metab Res, 2000)