Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. - Kubota,N.; Tobe,K.; Terauchi,Y.; Eto,K.; Yamauchi,T.; Suzuki,R.; Tsubamoto,Y.; Komeda,K.; Nakano,R.; Miki,H.; Satoh,S.; Sekihara,H.; et al. (Diabetes, 2000)