Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. - Ozata,M.; Ozdemir,I.; Licinio,J. (J Clin Endocrinol Metab, 1999)