The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin. - Kim,M.S.; Small,C.J.; Stanley,S.A.; Morgan,D.G.; Seal,L.J.; Kong,W.N.; Edwards,C.M.; Abusnana,S.; Sunter,D.; Ghatei,M.A.; Bloom,S.R. (J Clin Invest, 2000)