Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells. - Cardozo,A.K.; Ortis,F.; Storling,J.; Feng,Y.M.; Rasschaert,J.; Tonnesen,M.; Van Eylen,F.; Mandrup-Poulsen,T.; Herchuelz,A.; Eizirik,D.L. (Diabetes, 2005)