Inhibition of Tie-2 signaling induces endothelial cell apoptosis, decreases Akt signaling, and induces endothelial cell expression of the endogenous anti-angiogenic molecule, trombospondin-1. - Niu,Q.; Perruzzi,C.; Voskas,D.; Lawler,J.; Dumont,D.J.; Benjamin,L.E. (Cancer Biol Ther, 2004)