Atrophy is detectable within a 3-month period in untreated patients with active relapsing remitting multiple sclerosis. - Hardmeier,M.; Wagenpfeil,S.; Freitag,P.; Fisher,E.; Rudick,RA.; Kooijmans-Coutinho,M.; Clanet,M.; Radue,EW.; Kappos,L. (Arch Neurol, 2003)