Subunit composition of plasma von Willebrand Factor. Cleavage is present in normal individuals, increased in type IIA and IIB von Willebrand disease, but minimal in variants with aberrant structure of individual oligomers (types IIC, IID, and IIE) - Zimmerman, TS; Dent, JA; Ruggeri, ZM (J Clin Invest, 1986)