TY - JOUR AU - Segers, Kenneth; Dahlbäck, Björn; Nicolaes, Gerry A. F. TI - Coagulation factor V and thrombophilia: Background and mechanisms SN - 0340-6245 SN - 2567-689X PY - 2007 JO - Thromb Haemost JF - Thrombosis and Haemostasis LA - EN VL - 98 IS - 09 SP - 530 EP - 542 DA - 2017/11/28 KW - Factor V KW - coagulation KW - thrombosis KW - thrombophilia KW - protein C pathway AB - Human coagulation factor V (FV) is an essential coagulation protein with functions in both the pro- and anticoagulant pathways. Failure to express and control FV functions can either lead to bleeding, or to thromboembolic disease. Both events may develop into a life-threatening condition. Since the first description of APC resistance, and in particular the description of the so-called factor VLeiden mutation, in which a prominent activated protein C cleavage site in FV has been abolished through a mutation in the FV gene, FV has been in the center of attention of thrombosis research. In this review we describe how the functions of FV are expressed and regulated and provide an extensive description of the role that FV plays in the etiology of thromboembolic disease. PB - Schattauer GmbH DO - 10.1160/TH07-02-0150 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1160/TH07-02-0150 ER -