DOI: 10.1055/s-00000131

Synfacts

Issue 01 · Volume 20 · January 2024 · Sample Issue DOI: 10.1055/s-013-58754

Synform

A001
Zanda, Matteo: SYNFORM ISSUE 2024/01

Synthesis of Natural Products

z0001
All PDFs of this category
0001
Synthesis of (–)-Artatrovirenol A
0002
Total Synthesis of (–)-Erythroxylisin A
0003
Total Synthesis of (–)-Caulamidine D
0004
Syntheses of Eburnane Alkaloids
0005
Synthesis of (±)-19-Nordigitoxigenin
0006
Total Synthesis of (–)-Chamaecydin
0007
Total Synthesis of (±)-Marasmic Acid

Synthesis of Heterocycles

z0009
All PDFs of this category
0009
Reductive Cross-Coupling for C(sp2)–C(sp3) Bond Formation
0010
Regioselective 3-Trifluoromethylated Pyrrole Synthesis Using 2‑Bromo-3,3,3-trifluoropropene (BTP)
0011
Sustainable Approach to 2,5-Disubstituted 1,3,4-Oxadiazoles
0012
Enzyme-Catalyzed Synthesis of Chiral 3,3-Disubstituted Oxindoles
0013
Decarboxylative Coupling to Access Oxetanol Derivatives
0014
Modular, Scalable Synthesis of 1-Aza[3.3]heptanes
0015
One-Pot Conversion of Quinolines into Quinazolines
0016
Modular Synthesis of Isomeric, Spirocyclic Bioactive Scaffolds
0017
The Dual Role of Formic Acid in the Synthesis of N-Arylated Pyrroles from Nitroarenes
0018
Nickel-Catalyzed Synthesis of β-Lactams from Alkenyl Dioxazolones
0019
New Reagents Enable Regioselective Halogenation of Complex, Bioactive Scaffolds

Synthesis of Materials and Unnatural Products

z0021
All PDFs of this category
0021
Fluorinated N-Heterocyclic Carbenes from [3+2] Cyclization
0022
Closed- or Open-Shell? Ligand Matters
0023
Radical-Mediated Graphene Nanoribbon Synthesis
0024
A Dynamic Triangular Triradical
0025
New Method for Fullerene Functionalization
0026
Allied Organo- and Metal Catalysis in C–H Functionalization Polymerization
0027
Heteroaromatic Annulation by Deaminative Ring Contraction
0028
Hexa-Branched Nanographenes
0029
Dibenzanthracene with a Clear ‘Gulf’ Region
0030
Reversible Boron Insertion into Aromatic C–C Bonds
0031
Multigram Synthesis of 1,3-Disubstituted Cubane
0032
Degradable Polymers from Cascade Enyne Metathesis

Metals in Synthesis

z0033
All PDFs of this category
0033
Rhodium-Catalyzed Addition of Arylsilanes to Electrophiles by π-Coordination-Driven Desilylation
0034
Iron-Mediated Hydroazidation of Unactivated Alkenes with Bench-Stable NaN3 under Blue Light Irradiation
0035
Reversing the Reactivity of Palladium Hydrides Using Blue LED’s: Difunctionalization of Conjugated π-Systems
0036
Photocatalyzed sp3 C–H Chlorination Using FeCl3
0037
Bismuth-Catalyzed Conjugate Aminocyclization
0038
Stereodivergent Alkyne Carboration Enabled by Dual-Metal and Energy Transfer Catalysis
0039
Ligand-Controlled Regiodivergent Aminoalkylation of Alkyl Halides under Nickel/Photoredox Dual Catalysis
0040
Palladium-Catalyzed Synthesis of P-Stereogenic and Axially Chiral PHOX Ligands from Phosphonium Salts
0041
Palladium(I)-Catalyzed Cross-Electrophile Coupling of Vinyl Triflates and Aryl Iodides
0042
Pd-Catalyzed Carbonylation of Propargylic Acetates to Access Non-Symmetrical Diamides and Amido Esters
0043
Branched-Selective Ring-Opening Arylation of 2-Alkyl Aziridines with Aryl Iodides under Dual Ti/Ni Catalysis
0044
Synthesis of Borylated Tetrahydroquinolines via Low-Valent Cobalt Catalysis
0045
Photoinduced Hydropyridylation of Dienes with Pyridyl Phosphonium Salts under Cobalt Hydride Catalysis
0046
Palladium Hydride-Catalyzed Asymmetric Hydrofunctionalization of Dienes and Alkynes
0047
Palladium-Catalyzed Synthesis of α-Fluoro Olefins via C–H/C–F Coupling
0048
Copper-Catalyzed Hydro(borylmethylsilyl)ation of Alkynes
0049
Palladium/Blue Light Promoted Elimination of Primary Alkyl Bromides
0050
Iron-Catalyzed Direct Cross-Coupling of Arenes and Aliphatic Hydrocarbons under Visible-Light Irradiation
0051
Enantioconvergent and Diastereoselective Synthesis of Allylated Amides from Racemic Olefins
0052
Electrochemical Regiodivergent Hydroalkylation of Unactivated Alkenes under Nickel Hydride Catalysis
0053
Synthesis of Enantioenriched Phosphanyl Hydrazines Using Asymmetric Nickel Catalysis
0054
Asymmetric Nickel-Catalyzed Hydroarylation and Dicarbofunctionalization of Unactivated Alkenes
0055
Synthesis of Nanographenes via Gold-Catalyzed Double Hydroarylation of Alkynes
0056
A MHAT-Initiated Dowd–Beckwith-Type Ring Expansion to Access α-Quaternary Ketones
0057
Hegedus Indole Synthesis: Intramolecular Nucleopalladation of ortho-Allyl Aryl Nucleophiles
0058
Three-Component Aminocarboxylation of Alkenes under Dual Copper/Organophotoredox Catalysis

Polymer-Supported Synthesis

z0059
All PDFs of this category
0059
A Thermoresponsive Core-Shell Bifunctional Polymeric Catalyst: An Aldol-Michael-ATH Cascade Process
0060
C–H Functionalization of Arenes and Phenols with Alkynes Catalyzed by Palladium Nanoparticles
0061
Cleavage of C=C Bond to form Carbonyl Compounds by a Donor–Acceptor COF Photocatalyst
0062
Synthesis of Carbonyl Compounds from Carboxylic Acids, Alkenes, and Aryl Alkanes by mpg-Carbon Nitride
0063
Hydrosilylation of Olefins Using a Ru Complex Supported on SO4/ZrO2
0064
C(sp3)–C(sp3) Bond and C(sp2)–C(sp2) Bond Cleavage Catalyzed by an Fe Single-Atom Catalyst
0065
Synthesis of Quinolines through Dehydrogenative Cyclization by a Triazine-Based Microporous Polymer
0066
Aerobic Oxygenation of Styrenes by an N/O-Coordinated Cobalt Single-Atom Catalyst
0067
C−C Homo-Coupling of Benzylchlorides Using a Cu@ZnO Photocatalyst
0068
Photocatalytic Amination and Phosphonylation Using Porous Organic Polymers with Nickel
0069
Arylation of Allylic C(sp3)–H Bonds Promoted by Single Nickel Atom-Decorated CdS Quantum Dots

Organo- and Biocatalysis

z0071
All PDFs of this category
0071
Enynes Difluorination via Iodine(I/III) Catalysis
0072
Rendering Catalyst Alkylation Reversible Enables Conjugate Addition toward Fluoroalkyl γ-Nitroolefins
0073
Arenium Carborates Catalyze the Halodealkylation of Tetraalkyl Silanes
0074
Parallel Kinetic Resolution of Aziridines with Nucleophilic Water Aided by Acyloxy Borrowing
0075
Ene-Reductase: Catalyst for the Photoenzymatic Stereoselective Synthesis of Benzo-Fused Heterocycles
0076
One-Pot Asymmetric Synthesis of Oxa[5]helicene Scaffolds
0077
Tandem N-Heterocyclic Carbene/Photocatalysis Approach for the Synthesis of Amino Esters
0078
Photocatalytic syn-Selective Thioalkynylation, Thiovinylation and Thioallylation of Bicyclobutanes
0079
Stable Vinyl Sulfoxonium Ylides with Chiral Acyl Atropisomers
0080
Enantioselective C–C, C–O and C–N Bond Formation with Intermediacy of a Benzylic Secondary Cation

Innovative Drug Discovery and Development

z0081
All PDFs of this category
0081
Incorporation of 15N into Primary Amines via Isotopic Exchange
0082
1,2-Redox Transposition of Tertiary Amides Enable Access to β-Functionalized Amines
0083
A New Approach to the Tropane Alkaloids Enables Late-Stage Diversification
0084
Open-Source Python Tool PyParse: Automated, Flexible And Fast LC-MS Data Analysis of HTE Data
0085
Photolysis-Induced [3+2] Cycloaddition Enable a versatile Synthesis of Oxazoles
0086
Solvates Solve Purification Problems in Prospective Production Route for COVID-19 Drug Lufotrelvir
0087
Stereocontrolled α-Thiophosphate Transfer
0088
Azologing Vasopressin Provides a Light-Dependent V1bR Probe
0089
ABBV-CLS-484, an Orally Bioavailable, Dual PTPN1/PTPN2 Phosphatase Inhibitor with Antitumor Activity
0090
Concise Synthesis of SGLT2 Inhibitors
0091
Radical-Mediated Synthesis of α-Branched Enones
0092
Discovery of SHP2 Inhibitor GDC-1971 (RLY-1971) Containing a Pyrazolopyrazine Core
0093
Nickel-Catalyzed Enantioselective Cyclopropanation of Electron-Deficient Alkenes
0094
Visible-Light Promoted Photochemical Synthesis of Bulky Tertiary Alkylphosphonate Oligonucleotides
0095
A [4+2] Annulation Strategy towards Highly Functionalized 2-Pyridones
0096
Expedient Synthesis of (±)–Ibogamine
0097
A Spicy Total Synthesis

Peptide Chemistry

z0099
All PDFs of this category
0099
Electrochemical Pyridinyl Amino Acid Synthesis
0100
Synthesis of Fluorinated Amino Acids Catalyzed by a Palladium/Copper/Lithium Ternary System
0101
Late-Stage Modification of Oligopeptide Trp Units with Azoles
0102
Rhodium-Catalyzed Asymmetric N-Alkylation for the Synthesis of α-Amino Acids
0103
Direct Modification of Amino Acid Derivatives via Pd-Catalyzed δ-C(sp3)−H Thiolation
0104
Site-Selective Metal Free C7–H Borylation of Tryptophan
0105
Synergistic Photo-Redox Catalysis for Peptide Bond Formation
0106
Cu-Catalyzed N–H Insertion of Tryptamines to Form Unnatural Amino Acids
0107
Arndt–Eistert Reaction for the Synthesis of β-Amino Acids

Flow Chemistry

z0109
All PDFs of this category
0109
Rapid Access to Acyl Hydrazides in Continuous Flow