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CC BY 4.0 · Sustainability & Circularity NOW 2024; 01
DOI: 10.1055/a-2243-0268
Original Article

Continuous Flow Multigram-Scale Synthesis of Cetylpyridinium Chloride

Kashyap Patel
1   Department of Chemistry, Institute of Chemical Technology, Nathalal Parekh road, Matunga, Mumbai 400019, India
,
Anant R. Kapdi
1   Department of Chemistry, Institute of Chemical Technology, Nathalal Parekh road, Matunga, Mumbai 400019, India
,
Manish Manohar Shinde
2   Flow Chemistry Technology (FCT) Hub, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500046, India
,
Karuna Veeramani
2   Flow Chemistry Technology (FCT) Hub, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500046, India
,
Srinivas Oruganti
2   Flow Chemistry Technology (FCT) Hub, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500046, India
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Abstract

Cetylpyridinium chloride is popularly employed as an antimicrobial agent in high-volume commodity and consumer products. Given its high tonnage requirements annually, challenges in its synthesis using conventional batch manufacturing involving higher reaction temperatures at scale, lower yields and purity, and excessively long reaction times could be circumvented by adopting continuous flow as a safe and sustainable approach. We herein report a facile, gram-scale continuous flow protocol for the synthesis of cetylpyridinium chloride (CPC) that reduces reaction time from ≥24 hours to 30 minutes with an isolated product yield of >90% and an HPLC purity of >99%.

Keywords

Antimicrobial - Cetylpyridinium chloride - Continuous flow - High-T

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/a-2243-0268.
  • Supporting Information


Publication History

Received: 22 October 2023

Accepted after revision: 10 January 2024

Article published online:
25 January 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

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Bibliographical Record
Kashyap Patel, Anant R. Kapdi, Manish Manohar Shinde, Karuna Veeramani, Srinivas Oruganti. Continuous Flow Multigram-Scale Synthesis of Cetylpyridinium Chloride. Sustainability & Circularity NOW 2024; 01.
DOI: 10.1055/a-2243-0268
 

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