INFLUENCE OF BMI (BODY MASS INDEX) IN POLYP AND ADENOMA DETECTION IN GREEK PATIENTS; PRELIMINARY DATA

Aims The association of obesity with precancerous colorectal lesions is controversial. To assess if BMI correlates to the risk of colonic polyp and adenoma occurrence in a Greek cohort undergoing colonoscopy for the first time.

Methods Patients who underwent colonoscopy for the first time either for screening or diagnostic purposes were retrospectively included. Patients with IBD or polyposis syndrome were excluded. Demographics, colonoscopy and histology reports, history of drug, smoking, and medical history were reviewed from 01/05/2018 to 01/05/2019. BMI was evaluated before colonoscopy and stratified according to WHO classification.

Results Overall, 360 patients with a mean age of 59.9±11.7 years were included. 169 patients (46.94%) were males. 94 (26.11%) had BMI ≥30, 139 (38.61%) BMI 25-29.9 and 127(35.28%) BMI< 25. The majority (83.61%) underwent colonoscopy for screening purposes. Excellent preparation was noted in most cases (87.78%). In our study polyp (PDR) and adenoma detection rate (ADR) was 79.17% (95% C.I. 74.97-83.36) and 53.09% (95% C.I. 47.65-58.52), respectively. Our analysis revealed that male gender and age>60 were strongly associated with adenoma detection (p< 0,01). BMI did not correlate with the risk of polyp or adenoma development. However, there was a positive trend for BMIs 25-29.9, p=0,06. A very low positive correlation between BMI and the number (Spearman-R=0.16, p=0,01) or the size (Spearman-R=0.10, p=0,05) of polyps per patient was found.

Conclusions Preliminary data of our study have confirmed the positive correlation of age and male sex with adenoma detection. Overweight patients (BMI: 25.0-29.9 kg/m²) showed a trend (p=0,06) for higher polyp and adenoma detection rate.