Endoscopy 2021; 53(S 01): S53
DOI: 10.1055/s-0041-1724386
Abstracts | ESGE Days
ESGE Days 2021 Oral presentations
Friday, 26 March 2021 15:00 – 15:45 Colonic lesions: Improve your detection! Room 6

Does Endorings Improve the Adenoma Detection Rate at Colonoscopy? A Meta-Analysis Of Data from Individual Patients in Randomized Controlled Trials

L Frazzoni
1   University of Bologna, Department of Medical and Surgical Sciences, Bologna, Italy
,
S Thayalasekaran
2   Queen Alexandra Hospital, Endoscopy Unit, Portsmouth, United Kingdom
,
C Hassan
3   Nuovo Regina Margherita Hospital, Digestive Endoscopy Unit, Rome, Italy
,
DK Rex
4   Indiana University School of Medicine, Indianapolis, United States
,
PD Siersema
5   Radboud University Medical Center, Department of Gastroenterology and Hepatology, Nijmegen, Netherlands
,
L Fuccio
1   University of Bologna, Department of Medical and Surgical Sciences, Bologna, Italy
,
P Bhandari
2   Queen Alexandra Hospital, Endoscopy Unit, Portsmouth, United Kingdom
› Author Affiliations
› Further Information
Also available at
 

Aims Data on the impact of the EndoRings device on adenoma detection at colonoscopy is conflicting. The aim of this meta-analysis was to analyze individual patient based data from all the published trials to assess whether EndoRings improves the detection of colorectal adenomas.

Methods We searched MEDLINE/PubMed, Scopus and Scholar databases through May 2020 for randomized controlled trials that assessed detection of colorectal polyps by EndoRings vs. standard colonoscopy. We included studies whose authors provided data on individual patients. The primary outcome was adenoma detection rate (ADR). Patients with inadequate colon cleansing were excluded. A two-stage random-effect meta-analysis was applied to obtain pooled estimates as odds ratio (OR) and mean difference (MD) along with 95 % confidence interval (CI).

Results 5 studies published up to 2020, comprising 2,371 patients and 3,023 detected adenomas were included for quantitative synthesis. The ADR was slightly higher for EndoRingsTM arm vs. standard colonoscopy (637/1,188, 53.6 % vs. 581/1,183, 49.1 %; OR 1.21, CI 1.01-1.44). No significant difference was found when examining advanced ADR (297/1,188, 25 % vs. 284/1,183, 24 %; OR 1.08, CI 0.84-1.38), adenomas per colonoscopy (1,562/1,188 vs. 1,461/1,183; MD 0.11, CI -0.27 to 0.49), advanced adenomas per colonoscopy (194/1,188 vs. 225/1,183; MD -0.01, CI -0.12 to 0.10), right colon ADR (450/1,188, 37.9 % vs. 414/1,183, 35 %; OR 1.17, CI 0.93-1.49), right colon advanced ADR (63/1,188, 5.3 % vs. 72/1,183, 6.1 %; OR 0.91, CI 0.57-1.45), adenomas per colonoscopy in the right colon (808/1,188 vs. 719/1,183; MD 0.11, CI -0.12 to 0.33) and advanced adenomas per colonoscopy in the right colon (78/1,188 vs. 97/1,183; MD -0.01, CI -0.07 to 0.07).

Conclusions EndoRings marginally improves the detection of adenomas during colonoscopy, but not that of advanced adenomas nor other colonoscopy quality parameters. The clinical relevance of this add-on device is uncertain.

Citation: Frazzoni L, Thayalasekaran S, Hassan C et al. OP128 DOES ENDORINGS IMPROVE THE ADENOMA DETECTION RATE AT COLONOSCOPY? A META-ANALYSIS OF DATA FROM INDIVIDUAL PATIENTS IN RANDOMIZED CONTROLLED TRIALS. Endoscopy 2021; 53: S53.



Publication History

Article published online:
19 March 2021

© 2021. European Society of Gastrointestinal Endoscopy. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany