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Synlett 2000; 2000(8): 1163-1165
DOI: 10.1055/s-2000-6735
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A New Stereoselective Approach Towards the Galanthamine Ring System via an Intramolecular Heck Reaction

Christian Pilger* , Bernhard Westermann, Ulrich Flörke, Gregor Fels
  • *Universität Paderborn, Fachbereich 13 - Chemie und Chemietechnik, Warburger Str. 100, D-33098 Paderborn, Germany; Fax + 49 5251 60 32 45; E-mail: gf@chemie.uni-paderborn.de
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Publication Date:
31 December 2000 (online)

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We have developed a new synthetic access to the galanthamine ring structure employing a stereoselective intramolecular Heck reaction as the key step. Our route also allows for variation of the c- and d-ring sizes of galanthamine which has not been reported so far.

Alzheimer's Dementia - galanthamine - intramolecular Heck reaction

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