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Semin Thromb Hemost 2011; 37(2): 097-105
DOI: 10.1055/s-0030-1270334
© Thieme Medical Publishers

Plasminogen Activator Inhibitor-1 Gene Polymorphisms in Pre-Eclampsia

Angela V. D'Elia1 , Dora Fabbro1 , Lorenza Driul2 , Giovanni Barillari3 , Diego Marchesoni2 , Giuseppe Damante1 , 4
  • 1Istituto di Genetica Medica – AOUSMM Udine, at Udine, Italy
  • 2Dipartimento di Scienze Chirurgiche – Università di Udine, at Udine, Italy
  • 3Istituto di Medicina Trasfusionale – AOUSMM Udine, at Udine, Italy
  • 4Dipartimento di Scienze e Tecnologie Biomediche – Università di Udine, at Udine, Italy
Further Information

Publication History

Publication Date:
02 March 2011 (online)

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ABSTRACT

Pre-eclampsia (P-EC) is a multisystem disorder of pregnancy, characterized by new-onset hypertension and proteinuria. Deregulation of the coagulation cascade and hypofibrinolysis appear to play a central role in the development of this disease. After a brief review of the genetic basis of P-EC and the role of genes encoding proteins involved in coagulation, we focus on polymorphisms of the plasminogen activator inhibitor (PAI-1) gene. The most relevant association studies between PAI-1 gene polymorphisms and P-EC are reviewed. Results indicate that the 4G/4G genotype of the -675 4G/5G polymorphism represents a weak risk factor for P-EC.

KEYWORDS

Pre-eclampsia - gene polymorphisms - PAI-1

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Professor Giuseppe DamanteM.D. Ph.D. 

Dipartimento di Scienze e Tecnologie Biomediche

Università di Udine, Piazzale Kolbe 1, 33100 Udine, Italy

Email: giuseppe.damante@uniud.it

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