CAN THE PROKINETIC REDUCE THE TIME OF PASSAGE OF THE ENDOSCOPIC CAPSULE BY THE STOMACH WITHOUT SPEEDING UP THE PASSAGE THROUGH THE SMALL INTESTINE?

Aims:

Introduction: Excessive delay passage of endoscopic capsule (EC) by the stomach can reduce the examination time of the small intestine (SI). So too a very fast passage of the EC by SI can reduce the time of the SI exam, decreasing the diagnostic possibilities.

Objectives:

1. With the use of prokinetic (Pk) before, the passing time of the EC by the stomach can be reduced?;

2. Is there an acceleration effect in passage time by SI with Pk?

Methods:

The passage time of the EC by the stomach were evaluated in 71 patients that used Pk, and in 105 patients that not used Pk. Too was evaluated the passage time by SI in 62 patients who used Pk, and in 108 who didn't use PK. For both groups, was made a comparison between the group that used and no used Pk. The EC in all was PillCan brand (Given – Yokenan-Israel). The Pk was Domperidone (Motylium, Jansen Lab. USA), 10 mg oral 20 minutes before proceeding. The statistical test was the U Mann-Whitney test.

Results:

The time (median) passing through the EC by the stomach (PTS) in the group that used the Pk was 16 minutes, and in the group that did not use Pk was 29 min. The time (median) of the EC pass by the SI (PTSi) in patients who used Pk was 207 min, and that no used Pk was 216 min.

Conclusions:

1. Was observed a statistically significant difference (p = 0.015) in PTS comparative, with faster passage of EC by stomach in the group that used Pk.

2. In comparison of PTSi, statistically significant difference was not observed (p = 0.469).

This study has shown that Pk (Domperidone), had an effect in reducing the PTS, and no influence on the PTSi.