Outcomes Following Deep Brain Stimulation for Parkinson’s Disease: a Single Centre Experience

Introduction: Deep Brain Stimulation (DBS) for Parkinson’s disease (PD) is an established treatment for this condition.

Objectives: This is a review of outcomes following implantation of Deep Brain Stimulation for PD in a single Centre.

Methods: UPDRS, EQ-5D and PDQ-39 were recorded in pre-implantation and again 1 year post-implant. The prospectively collected data was analysed to assess outcomes.

Results: 108 patients PD had deep brain stimulators inserted from 2009 to 2016 with a mean age of 59 years (36–73). 102 STN target and 6 ZI target. Follow-up data were available for 50 patients. The mean PD-39 score pre-DBS was 65.08 and post DBS 53.64 (p < 0.01 Paired T-test). The EQ-5D score showed a reported improvement in self-care in 32% of patients, but only 2% reported improvement in mobility. The UPDRS was improved in all parameters except UPDRS-1. 82% of patients reported improvements in UPDRS-3 and UPDRS-4. 4 systems were explanted at 6 months, no mortality associated with the procedure. All patients had post-op imaging with no evidence of intracranial haematoma.

Conclusion: This is a large series in a single centre showing that deep brain stimulation for Parkinson’s disease is a safe and effective treatment. The results show that the most significant effects are in motor function and improvements in off states and fluctuations of symptoms. The overall quality of life has been shown to improve post-DBS implantation significantly.

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