Endoscopy 2019; 51(04): S164
DOI: 10.1055/s-0039-1681655
ESGE Days 2019 ePoster podium presentations
Friday, April 5, 2019 16:30 – 17:00: GI bleeding 5 ePoster Podium 6
Georg Thieme Verlag KG Stuttgart · New York

THE ROLE OF INFLAMMATORY MARKERS IN EARLY RE-BLEEDING RATES IN PATIENTS PRESENTING WITH ACUTE PEPTIC ULCER BLEEDING REQUIRING ENDOSCOPIC HAEMOSTASIS

N Viazis
1   Dept. of Gastroenterology, Evangelismos Hospital, Athens, Greece
,
H Keimali
1   Dept. of Gastroenterology, Evangelismos Hospital, Athens, Greece
,
I Papanikolaou
2   Hepato-Gastroenterology Unit, 2nd Dept. of Internal Medicine, Attikon University General Hospital, Athens, Greece
,
C Pontas
1   Dept. of Gastroenterology, Evangelismos Hospital, Athens, Greece
,
L Varytimiadis
1   Dept. of Gastroenterology, Evangelismos Hospital, Athens, Greece
,
A Sioulas
2   Hepato-Gastroenterology Unit, 2nd Dept. of Internal Medicine, Attikon University General Hospital, Athens, Greece
,
K Triantafyllou
2   Hepato-Gastroenterology Unit, 2nd Dept. of Internal Medicine, Attikon University General Hospital, Athens, Greece
,
V Smirniotis
3   4th Dept. of Surgery, Attikon University Hospital, Attikon University Hospital, University of Athens School of Medicine, Athens, Greece
,
N Arkadopoulos
3   4th Dept. of Surgery, Attikon University Hospital, Attikon University Hospital, University of Athens School of Medicine, Athens, Greece
,
G Mantzaris
1   Dept. of Gastroenterology, Evangelismos Hospital, Athens, Greece
› Author Affiliations
Further Information

Publication History

Publication Date:
18 March 2019 (online)

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    Aims:

    To identify the role of white blood cells, C-reactive protein and procalcitonin in the early re-bleeding rate of patients presenting with acute peptic ulcer bleeding that need endoscopic haemostasis.

    Methods:

    Prospective study conducted between February 2015 and February 2017 that included patients with active peptic ulcer bleeding, as confirmed by endoscopy, requiring endoscopic haemostasis. In order to test the correlation between inflammatory markers and early re-bleeding (up to 7 days following initial successful treatment), white blood cells (WBC), C-reactive protein (CRP) and procalcitonin (PCT) levels were analyzed before endoscopy (at admission day, day 0), and at days 3 and 7 after endoscopy.

    Results:

    The study sample consisted of 101 patients. The white blood cell count and the procalcitonin levels did not differ significantly between the 3 time points [F (1.898, 189.75)= 1.552, p = 0.215 and F (1.999, 199.86)= 0.949, p = 0.389) respectively]. However, the c-reactive protein levels were statistically significantly different between the 3 time points (F (1.990, 199.04)= 11.202, p < 0.005). Re-bleeding rate, at day 7, was significantly higher in patients with elevated CRP (values > 5 mg/dL) than those with normal CRP. 7 out of the 12 patients with early re-bleeding had elevated CRP as opposed to 21 out of the 89 patients that did not re-bleed during the first 7 days of admission, p = 0.011).

    Conclusions:

    CRP is significantly associated with re-bleeding in patients with peptic ulcer bleeding, within the first 7 days following endoscopic haemostasis and could therefore be tested as a screening indicator for predicting the risk or early re-bleeding in these patients.


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