FACTORS ASSOCIATED TO WOPN ENDOSCOPIC TREATMENT SUCCESS

Aims:

Endoscopic necrosectomy with metal stents, especially lumen apposition metal stents (LAMS), is increasingly being used for the treatment of complicated walled-off pancreatic necrosis (WOPN), but the need for necrosectomy is not well understood. The aim of this study is to evaluate clinical, endoscopic and radiologic predictors for the need of necrosectomy in patients treated with LAMS.

Methods:

Patients with WOPN treated with LAMS from 2014 to 2017 in our unit were retrospectively reviewed. Data was obtained from medical records and reviewed by endoscopist and radiologist. Clinical success was defined as the percentage of patients without need for surgery. Necrosectomy was performed only when clinically needed (i.e. fever or hemodynamic instability during follow-up). Predictors for the need of necrosectomy were evaluated with univariate analyses.

Results:

Eighteen patients were analyzed. Three were excluded due to early decease (2 intestinal perforation and 1 pancreatitis recurrence and advanced age). Among the remaining 15, 67% were men with mean age of 66 ± 14 years. One immediate adverse event occurred (7%) as the stent migrated to the gastric cavity during deployment, but was relocated in the same procedure. All 15 patients solved without need for surgery, but 5 (33%) required necrosectomy (4 multiple necrosectomy sessions, 1 only irrigation). The percentage of necrosis detected in the previous CT scan (47 ± 20% vs. 15 ± 18%, p = 0,008), and the purulent aspect of the fluid drained (100% vs. 40%; p = 0,044) predicted the need for necrosectomy in the univariable analysis, but only the first in the multivariable (p = 0,042). Other factors as age, gender, collection characteristics on CT scan (size, number, distance to stomach, or density) or EUS, or indication for drainage were not significant.

Conclusions:

Percentage of necrosis detected in the CT scan previous to WOPN drainage with LAMS might predict the need for necrosectomy.