Endoscopy 2020; 52(S 01): S257-S258
DOI: 10.1055/s-0040-1704806
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Thursday, April 23, 2020 09:00 – 17:00 Clinical endoscopic practice ePoster area
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THE IMPORTANCE OF INTRODUCING COLONOSCOPY SCREENING IN THE ADULT CYSTIC FIBROSIS PATIENTS: A SINGLE TERTIARY REFERRAL CENTRE ANALYSIS

J Doherty
1   Cork University Hospital, University College Cork, Department of Gastroenterology, Cork, Ireland
,
M McCarthy
2   University College Cork, Cork Centre for Cystic Fibrosis, Cork University Hospital, Cork, Ireland
,
C Fleming
3   Cork University Hospital, University College Cork, Cork Centre for Cystic Fibrosis, Cork, Ireland
,
C Shortt
3   Cork University Hospital, University College Cork, Cork Centre for Cystic Fibrosis, Cork, Ireland
,
S Zulquernain
1   Cork University Hospital, University College Cork, Department of Gastroenterology, Cork, Ireland
,
BJ Plant
3   Cork University Hospital, University College Cork, Cork Centre for Cystic Fibrosis, Cork, Ireland
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Publikationsdatum:
23. April 2020 (online)

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    Aims The risk of colorectal cancer (CRC) in patients with cystic fibrosis (PWCF) is 10times greater than the general population and 30times greater post-transplant. Due to this new screening guidelines were published in Gastroenterology by the CF Colorectal Cancer Screening Task Force in 2018. Our aim in this audit is to benchmark current practise at our centre against current guidelines.

    Methods Our endoscopy database was interrogated from 2012 to present to identify PWCF who received a previous colonoscopy.

    Results Group 1: PWCF non-transplant cohort; 161 patients were included. 26 were > 40 years. 4 had a previous colonoscopy. No colonoscopies were done for screening, all as patients were symptomatic. One patient had a polyp at colonoscopy. Adenoma detection rate (ADR) 25%.

    21 patients > 40 have no previous colonoscopy. Surveillance for CRC in this cohort has yet to be implemented with 0% compliance to date.

    Group 2: PWCF post solid-organ transplant; 16 patients were included. 13 were > 30 years. 11 patients had a previous colonoscopy (total number colonoscopies = 20). Reasons for index colonoscopy: 5 screening, 3 symptomatic, 3 no indication on report. 10 colonoscopies in total were done for screening. 3 patients had polyps found at index colonoscopy (2 adenomas high grade dysplasia, 4 adenomas low grade dysplasia) and surveillance colonoscopies was arranged subsequently. ADR was 27.27%. Current practise in the post transplant cohort is close to new recommendations with 84% compliance however only 45.45% of index colonoscopies were done initially for screening.

    Conclusions Current guidelines are only in existence over 12 months. Our analysis suggests there is an awareness of the need for CRC screening in the post-transplant cohort but there is need for improvement. In PWCF with no previous transplant screening has not been a priority and needs to be implemented. Currently we are implementing a screening programme in keeping with current guidelines.


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