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Synfacts 2020; 16(10): 1237
DOI: 10.1055/s-0040-1707360
DOI: 10.1055/s-0040-1707360
Peptide Chemistry
Coupling of Amino Acids and α-Branched Aldehydes
Tobiesen HN,
Leth LA,
Iversen MV,
Næsborg L,
Bertelsen S,
Jørgensen KA.
*
Aarhus University, Denmark
Stereoselective Oxidative Bioconjugation of Amino Acids and Oligopeptides to Aldehydes.
Angew. Chem. Int. Ed. 2020;
DOI: 10.1002/anie.202008513.
Stereoselective Oxidative Bioconjugation of Amino Acids and Oligopeptides to Aldehydes.
Angew. Chem. Int. Ed. 2020;
DOI: 10.1002/anie.202008513.
Key words
metal-free - organocatalysis - bioconjugation - amino acids - aldehydes - asymmetric reaction
Significance
The synthesis of modified amino acids is significant in the pharmaceutical industry and in medicinal chemistry. The authors used a metal-free oxidative bioconjugation method to couple amino acids and aldehydes.
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Comment
Various amino acid esters are synthesized from amino acids and α-branched aldehydes. The yields of the reactions were moderate to good, and the stereoselectivities were good.
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Publication History
Article published online:
17 September 2020
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