Endoscopy 2021; 53(S 01): S46-S47
DOI: 10.1055/s-0041-1724369
Abstracts | ESGE Days
ESGE Days 2021 Oral presentations
Friday, 26 March 2021 12:00 – 12:45 EUS gastroenterostomy: A new gold standard for managing gastric outlet obstruction? Room 5

Prospective and Multicenter Evaluation of the Impact Of Eus-Guided Gastroenterostomy (EUS-GE) On The Quality Of Life Of Patients With Malignant Gastric Outlet Obstruction (GOO)

FJ Garcia Alonso
1   Hospital Universitario Río Hortega, Gastroenterology, Valladolid, Spain
,
V Martín-Álvarez
1   Hospital Universitario Río Hortega, Gastroenterology, Valladolid, Spain
,
C Chavarria
1   Hospital Universitario Río Hortega, Gastroenterology, Valladolid, Spain
,
JR Aparicio
2   Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante, ISABIAL, Gastroenterology, Alicante, Spain
,
B Martinez-Moreno
2   Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante, ISABIAL, Gastroenterology, Alicante, Spain
,
JC Subtil
3   Clínica Universidad de Navarra, Pamplona, Spain
,
JJ Vila
4   Complejo Hospitalario de Navarra, Gastroenterology, Pamplona, Spain
,
V Busto Bea
4   Complejo Hospitalario de Navarra, Gastroenterology, Pamplona, Spain
,
C de la Serna-Higuera
1   Hospital Universitario Río Hortega, Gastroenterology, Valladolid, Spain
,
M Perez-Miranda
1   Hospital Universitario Río Hortega, Gastroenterology, Valladolid, Spain
› Author Affiliations
› Further Information
Also available at
 
 

    Aims EUS-guided gastroenterostomy is emerging as an alternative for GOO. To date no studies have assessed the effect of EUS-GE on patients’ quality of life (QoL).

    Methods Prospective multicenter study including consecutive patients with unresectable malignant GOO undergoing primary EUS-GE performed by the orojejunal catheter method. The European Organization for Research and Treatment of Cancer (EORTC) questionnaire EORTC-QLQ-C30 was used to assess QoL at baseline and 1 month after the procedure withscores rangingfrom 0 to 100. Oral intake was assessed using the Gastric Outlet Obstruction Scoring System (GOOSS). Differences between the different outcomes of the EORTC-QLQ-C30 were assessed using linear mixed models with fixed effects for baseline values, and interaction with oncological treatment.

    Results A total of 38 patients from 4 centers, including 20 (52.6 %) males, with a median age of 77.3 years (IQR: 65.3-84.4) were included between August 2019-November 2020. Most frequent diagnoses were gastric (n=14;36.8 %) and pancreatic adenocarcinoma (n=11;29 %); twenty-two (57.9 %) presented metastatic disease. Before EUS-GE, 20 (52.6 %) tolerated no oral intake, 11 were on liquids only and 7 (18.4 %) were on a soft diet.

    Median time until discharge was 5 days (IQR: 2-6). Thirty days after the procedure, 81[MJP1] .5 % reached clinical success (GOOSS ≥2). Overall, 51.6 % of patients received post-procedure palliative chemotherapy.

    Overall, global health status improved after EUS-GE (Initial score: 33.3 (16.7-66.6), Final score: 66.6 (33.3-83.3), p = 0.01). [Table 1] includes all functional scales, where no relevant changes were observed. Statistically significant improvements were seen in appetite loss (Initial: 66.6 (0-100), final: 0 (0-66.7), p = 0.02), pain (Initial: 33.3 (0-66.7), final: 0 (0-16.7), p = 0.02), and nausea and vomiting (Initial 50 (25-100), final 0 (0-16.7), p<0.001).

    Tab. 1

    Physical functioning, med (IQR)

    73.3 (33.3-96.7)

    73.3 (33.3-86.7)

    p = 0.77

    Role functioning, med (IQR)

    33.3 (16.7-66.7)

    66.6 (33.3-100)

    p = 0.09

    Emotional functioning, med (IQR)

    70.8 (41.7-83.3)

    83.3 (75-100)

    p = 0.06

    Cognitive functioning, med (IQR)

    83.3 (66.7-100)

    100 (66.7-100)

    p = 0.31

    Social functioning, med (IQR)

    58.3 (33.3-91.7)

    66.7 (33.3-100)

    p = 0.62

    Conclusions EUS-GE allowed a soft/normal diet in 81.5 % of patients and significantly improved the global health status score at one month. Significant reductions in pain, loss of appetite and nausea/vomiting were noted.

    Citation: Garcia Alonso FJ, Martín-Álvarez V, Chavarria C et al. OP110 PROSPECTIVE AND MULTICENTER EVALUATION OF THE IMPACT OF EUS-GUIDED GASTROENTEROSTOMY (EUS-GE) ON THE QUALITY OF LIFE OF PATIENTS WITH MALIGNANT GASTRIC OUTLET OBSTRUCTION (GOO). Endoscopy 2021; 53: S46.


    #

    Publication History

    Article published online:
    19 March 2021

    © 2021. European Society of Gastrointestinal Endoscopy. All rights reserved.

    Georg Thieme Verlag KG
    Rüdigerstraße 14, 70469 Stuttgart, Germany