Endoscopy 2021; 53(S 01): S53-S54
DOI: 10.1055/s-0041-1724388
Abstracts | ESGE Days
ESGE Days 2021 Oral presentations
Friday, 26 March 2021 15:00 – 15:45 Colonic lesions: Improve your detection! Room 6

Endocuff Vision Improves ADR in Low Detectors: Results of the “Itavision” Randomized Controlled Trial

G Antonelli
1   Nuovo Regina Margherita Hospital, Digestive Endoscopy Unit, Rome, Italy
2   Sapienza University of Rome, Department of Translational and Precision Medicine, Rome, Italy
,
M Zorzi
3   Azienda Zero, Veneto Tumor Registry, Padova, Italy
,
C Senore
4   University Hospital Città della Salute e della Scienza, Epidemiology and Screening Unit – CPO, Torino, Italy
,
C Hassan
1   Nuovo Regina Margherita Hospital, Digestive Endoscopy Unit, Rome, Italy
› Author Affiliations
› Further Information
Also available at
 
 

    Aims Endocuff Vision (EV, Arc Medical Design Ltd., Leeds, England) has shown to increase mucosal exposure, and consequently adenoma detection rate (ADR), during colonoscopy, but its role in positive Faecal Immunochemical Test (FIT+) subjects within an organised colorectal cancer population-based screening program is uncertain. This nationwide multicentre study aims to assess possible benefits and harms of implementing EV in a FIT-based screening program.

    Methods Patients undergoing colonoscopy after a FIT+, were randomised 1:1 between standard colonoscopy with EV and control, stratified by gender, age, and screening history. Primary outcome was ADR, stratified by patient gender, age, and by endoscopists’ ADR. Secondary outcomes were advanced ADR (AADR), adenoma per colonoscopy (APC), polyps per colonoscopy, withdrawal time (WT), adverse events (AE). All outcomes were adjusted at multivariate analysis.

    Results Overall, 1,864 patients in 13 centers (males: 53.7 %) were randomised, 908 in the EV arm and 905 in the control. No patients’ demographic or procedural characteristics differed among the two groups. ADR was significantly higher in the EV arm (47.8 % vs 40.8 %; RR 1.17, 95 %CI 1.06-1.30; p=0.002) with no differences among groups regarding size or morphology. When stratifying for endoscopists’ ADR, only low detectors (ADR< 33.3 %) showed a significant ADR increase (EV = 41.1 % vs control = 26 %; ADR difference +15.1 %; 95 %CI 7.5-22.7; p<0.001). AADR (24.8 % vs. 20.5 %, RR 1.21; 95 %CI 1.02-1.43; p=0.03) and APC (0.94 vs. 0.77, p=0.001) were significantly increased in the EV group. WT and AE were similar among the two groups.

    Conclusions EV increased ADR in a FIT-based, organised CRC-screening program, supporting a complete exploration of colonic mucosa. Its utility was highest among endoscopists with a low ADR.

    Citation: Antonelli G, Zorzi M, Senore C et al. OP130 ENDOCUFF VISION IMPROVES ADR IN LOW DETECTORS: RESULTS OF THE “ITAVISION” RANDOMIZED CONTROLLED TRIAL. Endoscopy 2021; 53: S53.


    #

    Publication History

    Article published online:
    19 March 2021

    © 2021. European Society of Gastrointestinal Endoscopy. All rights reserved.

    Georg Thieme Verlag KG
    Rüdigerstraße 14, 70469 Stuttgart, Germany