Patient Preference for Colon Capsule Endoscopy or Colonoscopy in Population-Based Colorectal Cancer Screening: Interim Analysis of First 39,076 Invitations for Fecal Immunochemical test in Careforcolon2015

Aims To compare participation rates for fecal immunochemical test (FIT) prior to offering colon capsule endoscopy (CCE) or colonoscopy with controls offered only colonoscopy as follow-up to positive FIT, and to analyze the choice of screening method in the intervention group within the large randomized clinical trial CareForColon2015[ ¹ ].

Methods Individuals are being randomized into two groups: control group with regular colorectal cancer screening (FIT followed by colonoscopy) or intervention group introducing CCE as an optional filter test before a potential colonoscopy. These interim analyses were conducted after 39,076 invitations had been distributed. Participation rates for FIT within each group were calculated. Preference distribution within the intervention group was calculated and then tested against an equal distribution using the chi-squared test.

Results During the first 86 days of invitations, 19,388 invitations for the control group and 19,688 for the intervention group were distributed. After six weeks of follow-up, 11,525 (59.4 %) had returned a FIT sample within the control group. In the intervention group, 11,691 (59.4 %) had returned a FIT sample, from which 5,879 (50.3 %) indicated preferring CCE, 1,186 (10.1 %) preferred colonoscopy while 4,626 (39.6 %) gave no indication of preference (Fig. 1). The preference for CCE was significantly more prevalent than that for colonoscopy (p < 0.001).

Conclusions The participation rates for FIT were equal between control group and intervention group. In the intervention group, more participants preferred CCE than did colonoscopy, although a substantial proportion did not indicate their preference. The patient information material will be reviewed in order to optimize response rate for preference of initial follow-up investigation during the remainder of the trial.

Citation: Deding U, Bjørsum-Meyer T, Kaalby L et al. OP236 PATIENT PREFERENCE FOR COLON CAPSULE ENDOSCOPY OR COLONOSCOPY IN POPULATION-BASED COLORECTAL CANCER SCREENING: INTERIM ANALYSIS OF FIRST 39,076 INVITATIONS FOR FECAL IMMUNOCHEMICAL TEST IN CAREFORCOLON2015. Endoscopy 2021; 53: S96.

• 1 Møller LK, Deding U, Kobaek-Larsen M, Havshoi ALV, Zimmerman-Nielsen E, Thygesen MK, Kroijer R, Bjørsum-Meyer T, Baatrup G. Colon capsule endoscopy in colorectal cancer screening: a randomized controlled trial. BMJ Open Gastro 2020; 7: e000411. DOI: 10.1136/bmjgast-2020-000411.

Publication History

Article published online:
19 March 2021