Endoscopy 2021; 53(S 01): S127-S128
DOI: 10.1055/s-0041-1724595
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Capsule Endoscopy Findings Reflect the Gastrointestinal Conditions in Patients With Systemic Scleroderma

S Iio
1   Hiroshima University, Department of Endoscopy, Hiroshima, Japan
,
S Oka
2   Hiroshima University, Department of Gastroenterology and Metabolism, Hiroshima, Japan
,
S Tanaka
1   Hiroshima University, Department of Endoscopy, Hiroshima, Japan
,
A Sumioka
2   Hiroshima University, Department of Gastroenterology and Metabolism, Hiroshima, Japan
,
A Tsuboi
2   Hiroshima University, Department of Gastroenterology and Metabolism, Hiroshima, Japan
,
T Nojima
3   Hiroshima University, Department of Clinical Immunology and Rheumatology, Hiroshima, Japan
,
S Hirata
3   Hiroshima University, Department of Clinical Immunology and Rheumatology, Hiroshima, Japan
,
Y Matsuo
4   Hiroshima University, Department of Dermatology, Hiroshima, Japan
,
E Sugiyama
3   Hiroshima University, Department of Clinical Immunology and Rheumatology, Hiroshima, Japan
,
M Hide
4   Hiroshima University, Department of Dermatology, Hiroshima, Japan
,
K Arihiro
5   Hiroshima University, Department of Anatomical Pathology, Hiroshima, Japan
,
K Chayama
2   Hiroshima University, Department of Gastroenterology and Metabolism, Hiroshima, Japan
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    Aims Systemic scleroderma (SSc) is characterized by chronic progressive systemic organ fibrosis. However, frequency and characteristics of small-bowel lesions in SSc patients are still unclear. This study aimed to evaluate the clinical state of SSc patients using capsule endoscopy (CE).

    Methods A total of 65 consecutive patients with SSc (61 females; mean age, 64.3 years) underwent CE at Hiroshima University Hospital between April 2012 and December 2019. We compared the average capsule transit time of the esophagus, stomach and small-bowel, total small-bowel observation rate and characteristics and detection rate of small-bowel lesions between diffuse cutaneous SSc (dcSSc) and limited cutaneous SSc (lcSSc) patients, and between patients with fibrosis and those without it. Capsule endoscopy was performed using a PillCam SB2 or SB3 capsule (Covidien, Mansfield, MA, USA).

    Results Small-bowel lesions were detected in 27 (42 %) SSc patients. Type 1b angioectasias were significantly more frequent in lcSSc patients than in dcSSc patients (P = 0.0071). There was no significant difference in sex, mean age, or medication. The average capsule transit time in the esophagus was significantly longer in dcSSc patients than in lcSSc patients (P = 0.0418). Moreover, angioectasia, especially Type 1a angioectasia, was more frequent in the gastrointestinal tract in SSc patients without fibrosis than in those with it, and the average capsule transit time in the esophagus was significantly longer in SSc patients with fibrosis than in those without it.

    Conclusions CE is considered as a useful modality for identification of small-bowel lesions in SSc patients and diagnosis of angioectasia in lcSSc patients. Also, CE can evaluate the different average capsule transit between lcSSc and dcSSc patients, as well as between SSc patients with fibrosis and those without it.

    Citation: Iio S, Oka S, Tanaka S et al. eP96 CAPSULE ENDOSCOPY FINDINGS REFLECT THE GASTROINTESTINAL CONDITIONS IN PATIENTS WITH SYSTEMIC SCLERODERMA. Endoscopy 2021; 53: S127.


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    Publication History

    Article published online:
    19 March 2021

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