Post-ERCP Pancreatitis Is Not Influenced By The Time To Ercp In Non-Ercp Emergencies

Aims The aim of this study was to assess if time to ERCP (TtE) is a risk factor for post-ERCP pancreatitis (PEP) or if TtE is influencing hospitalization days in patients with biliary obstruction.

Methods We analyzed patients that undergone ERCP during a period of 12 months in our Gastroenterology department. The TtE was quantified per each patient and analyzed if the TtE influenced the PEP development or the patient hospitalization time in patients without acute cholangitis. We excluded from our study patients with acute cholangitis and those with previous ERCP.

Results Out of 251 patients ERCP’s, 67.3 % had benign causes of biliary obstruction. Overall incidence of PEP was 6.8 % (17/251). 43 % (108/251) of the patients had TtE at 24-48 h, out of which 5.5 % (6/108) developed PEP. TtE at 48- 72 h were 37.5 % (94/251) patients, out of which 6.4 % (6/94) developed PEP. TtE at >72h were 16.7 % (42/251) out of which 12 % (5/42) developed PEP. Odds ratio for performing ERCP after 24-48 h showed increased risk of developing PEP, OR=1.5, 95 % CI (0.53-4.18) p=0.447. If we take a cut off value for common hospitalization days after ERCP of 3 days, there was a significant difference between groups according to TtE, 26 % (28/108)- (ERCP <24h) had >3 days of hospitalization vs. 84 % (114/136)-ERCP>24h, p<0.0001. Delaying time to ERCP leads to a prolonged time of hospitalization days with an OR=14.8, 95 % CI (7.9-27), p<0.0001. The etiology of obstruction did not influenced the risk of PE, 58.8 % of cases had a benign cause of obstruction and 41.2 % had a malignant cause p=0.3120.

Conclusions The odds ratio for TtE after 24h for developing PEP was of low significance but the hospitalization days were statistically significant if we delay TtE for more than 24h. The etiology of obstruction did not influence the PEP.

Citation Moga T, Miutescu B, Ghiuchici AM et al. eP343 POST-ERCP PANCREATITIS IS NOT INFLUENCED BY THE TIME TO ERCP IN NON-ERCP EMERGENCIES. Endoscopy 2021; 53: S209.

Publication History

Article published online:
19 March 2021