Endoscopy 2021; 53(S 01): S250
DOI: 10.1055/s-0041-1724953
Abstracts | ESGE Days
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The Role Of Spectral Focused Imaging In Diagnosing Subtle Mucosal Changes In Ulcerative Colitis Patients

A Ghidersa
1   Bucharest Emergency University Hospital, Department of Gastroenterology, Bucharest, Romania
2   Carol Davila University of Medicine and Pharmacy of Bucharest, Bucharest, Romania
,
Tîrcol SA
1   Bucharest Emergency University Hospital, Department of Gastroenterology, Bucharest, Romania
2   Carol Davila University of Medicine and Pharmacy of Bucharest, Bucharest, Romania
,
L Negreanu
1   Bucharest Emergency University Hospital, Department of Gastroenterology, Bucharest, Romania
2   Carol Davila University of Medicine and Pharmacy of Bucharest, Bucharest, Romania
,
M State
3   Colentina Clinical Hospital, Department of Gastroenterology, Bucharest, Romania
2   Carol Davila University of Medicine and Pharmacy of Bucharest, Bucharest, Romania
,
A Dumitru
4   Bucharest Emergency University Hospital, Department of Pathology, Bucharest, Romania
2   Carol Davila University of Medicine and Pharmacy of Bucharest, Bucharest, Romania
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    Aims The aim of this pilot study was to determine whether virtual chromoendoscopy, represented by SFI, a new optical chromoendoscopy system (from SonoScape) has the potential to enhance the rate of detection for subtle mucosal changes in patients with mild or inactive forms of ulcerative colitis (UC) in comparison to high definition white light endoscopy (HD-WLE).

    Methods A group of 12 patients with UC were randomly assigned at a 1:1 ratio to undergo colonoscopy with high-definition white light (group A) or SFI (group B). The mucosal pattern, location of mucosal changes (measured in centimeters from the anal verge), morphology, size and duration of the endoscopic procedure were recorded, while disease activity was established following the Mayo Endoscopic Subscore for ulcerative colitis. Subsequent to endoscopic characterization, targeted biopsies (or random biopsies in case of normal colonic mucosa) were obtained from every segment for histopathological follow-up analysis.

    Results The median endoscopic activity index, based on the Mayo ulcerative colitis endoscopic score, was 1 for both groups of patients. Taking into account the duration of the examination, the median value was 17.3 minutes in group A and 18.5 minutes in group B. Upon examining the concordance between endoscopic prediction of disease activity and histological findings, we obtained a 55 % degree of conformity in group A, compared to a degree of 90 % in group B.

    Conclusions The pilot study performed has shown that image enhanced endoscopy using SFI might increase the rate of detection and demarcation for subtle inflammatory changes in the mucosa, correlating with potential histologic activity. Furthermore, this diagnostic tool could provide a more accurate and early identification for areas of minimal inflammation than the conventional techniques.

    Citation Ghidersa A, Tîrcol SA, Negreanu L et al. eP464 THE ROLE OF SPECTRAL FOCUSED IMAGING IN DIAGNOSING SUBTLE MUCOSAL CHANGES IN ULCERATIVE COLITIS PATIENTS. Endoscopy 2021; 53: S250.


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    Publication History

    Article published online:
    19 March 2021

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