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Horm Metab Res 1975; 7(5): 432-437
DOI: 10.1055/s-0028-1093700
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© Georg Thieme Verlag KG Stuttgart · New York

In Vitro Studies of Calcitonin Release in Man

Helena P. Selawry [*] , K. L. Becker , L. E. Bivins , R. H. Snider , O. L. Silva
  • Section of Metabolism, Veterans Administration Hospital, Washington, D.C., and Department of Medicine, George Washington and Georgetown University, Washington, D.C, U.S.A.
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Publikationsdatum:
23. Dezember 2008 (online)

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Abstract

The influence of various agents on calcitonin release from human thyroid was studied in vitro. Under the conditions of this investigation, calcium, magnesium and phosphate did not stimulate calcitonin release from short-term incubated slices of human thyroid. However, pentagastrin and USP glucagon were potent stimulators of calcitonin release. Theophylline and dibutyryl cyclic AMP were also potent stimuli. A highly purified preparation of pancreatic glucagon was without an effect. Those agents which stimulated calcitonin release were associated with augmented cyclic AMP accumulation. Although maximal discharge of calcitonin required the presence of calcium, our in vitro experiments raise the question as to whether a gastrointestinal hormone, rather than calcium, might not be the principal agent affecting calcitonin release.

Key words

Calcitonin - Human Thyroid - Calcium - Gastrointestinal Hormone

1 Present address: Division of Endocrinology and Metabolism, Department of Medicine, University of Miami School of Medicine, P.O. Box 520875, Biscayne Annex, Miami, Florida 33152, USA.

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