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Horm Metab Res 1975; 7(4): 275-278
DOI: 10.1055/s-0028-1093753
DOI: 10.1055/s-0028-1093753
Originals
© Georg Thieme Verlag KG Stuttgart · New York
Growth Hormone Secretion in the Rat as a Function of Age
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
23. Dezember 2008 (online)
Abstract
The first appearance of rat growth hormone (RGH) in serum was in the 19 day-old foetus. The level was high on the 21st day of gestation (129 ± 7 ng/ml serum), it decreased after birth and descended to 17 ± 2 ng/ml in the 15 day-old rat. After weanling it again rose to reach a plateau at 80 days.
The half-life and metabolic clearance rate (MCR) of RGH were compared in the 4 and 15 day-old rat and in normal and hypophysectomized adult rats after a single intravenous injection of hormone. As the MCR was essentially the same in all groups, serum RGH levels reflect the rate of hormonal secretion of the pituitary gland.
Key words
Rat Growth Hormone - Development - Half-Life - Metabolic Clearance Rate