Horm Metab Res 1975; 7(4): 275-278
DOI: 10.1055/s-0028-1093753
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© Georg Thieme Verlag KG Stuttgart · New York

Growth Hormone Secretion in the Rat as a Function of Age

M. Th. Strosser , P.  Mialhe
  • Laboratoire de Physiologie Générale, rue René Descartes, Strasbourg, France (ERA 188, CNRS and INSERM)
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Publikationsverlauf

Publikationsdatum:
23. Dezember 2008 (online)

Abstract

The first appearance of rat growth hormone (RGH) in serum was in the 19 day-old foetus. The level was high on the 21st day of gestation (129 ± 7 ng/ml serum), it decreased after birth and descended to 17 ± 2 ng/ml in the 15 day-old rat. After weanling it again rose to reach a plateau at 80 days.

The half-life and metabolic clearance rate (MCR) of RGH were compared in the 4 and 15 day-old rat and in normal and hypophysectomized adult rats after a single intravenous injection of hormone. As the MCR was essentially the same in all groups, serum RGH levels reflect the rate of hormonal secretion of the pituitary gland.

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