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Exp Clin Endocrinol Diabetes 1984; 83(3): 310-314
DOI: 10.1055/s-0029-1210346
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Influence of STS 557 on the Mitotic Activity in the Endometrium of Ovariectomized Mice and Comparison with the Effects of Progesterone and Levonorgestrel

M. Koch
  • Department of Experimental Endocrinology, Division of Steroid Hormone Research (Head: Prof. Dr. K. Schubert), Central Institute of Microbiology and Experimental Therapy (Director: Prof. Dr. U. Taubeneck), Academy of Sciences of the GDR, Jena/GDR
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Publication History

1982

Publication Date:
17 July 2009 (online)

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Summary

The numbers of mitoses in the epithelial and stromal tissues of mouse uteri were recorded after treatment with various doses of progesterone (P), levonorgestrel (LN), and STS 557 (17 α-cyanomethyl-17 β-hydroxy-estra-4,9(10)-diene-3-one). All three progestins induced mitotic activity in the stromal tissue of the endometrium in which P and LN were much more active than STS 557.

While the cell divisions in the luminal and glandular epithelium induced by P were only rare, LN and STS 557 enhanced the mitosis rates in these tissues significantly at a daily dose of 1.0 mg/ animal on 5 consecutive days. The results are discussed with special regard to the post-coital antifertility effect of STS 557.

Key words

Progestins - mitotic activity - mouse uterus

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