PDF herunterladen
Horm Metab Res 2013; 45(01): 43-46
DOI: 10.1055/s-0032-1323679
Humans, Clinical
© Georg Thieme Verlag KG Stuttgart · New York

Normal Circulating PTH in Saudi Healthy Individuals with Hypovitaminosis D

Y. Al-Saleh
1   Prince Mutaib Chair for Biomarkers of Osteoporosis, King Saud University, Riyadh, KSA
2   College of Medicine, King Saud University of Health Sciences, Riyadh, KSA
,
N. M. Al-Daghri
1   Prince Mutaib Chair for Biomarkers of Osteoporosis, King Saud University, Riyadh, KSA
3   Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, KSA
4   Center of Excellence in Biotechnology Research Center, King Saud University, Riyadh, KSA
,
K. M. Alkharfy
1   Prince Mutaib Chair for Biomarkers of Osteoporosis, King Saud University, Riyadh, KSA
2   College of Medicine, King Saud University of Health Sciences, Riyadh, KSA
5   Clinical Pharmacy Department, College of Pharmacy, King Saud University, Riyadh, KSA
,
O. S. Al-Attas
1   Prince Mutaib Chair for Biomarkers of Osteoporosis, King Saud University, Riyadh, KSA
3   Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, KSA
4   Center of Excellence in Biotechnology Research Center, King Saud University, Riyadh, KSA
,
M. S. Alokail
1   Prince Mutaib Chair for Biomarkers of Osteoporosis, King Saud University, Riyadh, KSA
3   Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, KSA
4   Center of Excellence in Biotechnology Research Center, King Saud University, Riyadh, KSA
,
A. Al-Othman
6   College of Applied Medical Sciences, King Saud University, Riyadh, KSA
,
S. Sabico
3   Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, KSA
,
G. P. Chrousos
3   Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, KSA
7   First Department of Pediatrics, Athens University Medical School, Athens, Greece
› Institutsangaben
Weitere Informationen

Publikationsverlauf

received 12. Mai 2012

accepted 23. Juli 2012

Publikationsdatum:
12. September 2012 (online)

Auch verfügbar auf
    Lizenzen und Reprints

Abstract

Recent studies in the Middle East have shown an increased incidence of vitamin D deficiency across this region of year-round sunlight. There is scarcity of information, however, as to the levels of 1,25-dihydroxyvitamin D [1,25(OH)2D], the active form of vitamin D, and its associations with cardiometabolic parameters in an Arab cohort and this study aims to fill this gap. In a cross-sectional study, 33 male and 43 female (22 children and 54 adults, total 76) Saudis with previously established low levels of serum 25-hydroxyvitamin D [25(OH)D] (<50 ng/ml or 20 nmol/l) were recruited. Anthropometrics were obtained and fasting blood samples were taken for a routine measurement of glucose, lipid profile, calcium, and albumin, while serum 25(OH)D, 1,25-(OH)2D, and intact PTH were quantified using specific ELISAs. Serum calcium, intact PTH, and 1,25(OH)2D were all within the normal range in both children and adults in both genders. In all subjects, serum 1,25(OH)2D was not associated with intact PTH, while circulating 1,25(OH)D inversely correlated with systolic blood pressure (p=0.01) and waist circumference (p=0.04). Thus, vitamin D deficient Saudi children and adults with normal levels of 1,25-(OH)2D also had normal circulating calcium and PTH. This study suggests that local cutoffs should be set that will be of clinical significance in the identification of those at true risk for harder end-points, such as secondary hyperparathyroidism and bone-related diseases.

Key words

vitamin D - 1, 25-dihydroxyvitamin D - PTH - Saudi Arab
 

  • References

  • 1 Mithal DA, Wahl JP, Bonjour P, Burckhardt B, Dawson-Hughes JA, Eisman G, El-Hajj F, Josse RG, Lips P, Morales-Torres J. IOF Committee of Scientific Advisors (CSA) Nutrition Working Group . Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 2009; 20: 1807-1820
    CrossrefPubMedGoogle Scholar
  • 2 Van Schoor NM, Lips P. Worldwide vitamin D status. Best Pract Res Clin Endocrinol Metab 2011; 25: 671-680
    CrossrefPubMedGoogle Scholar
  • 3 Fields J, Trivedi NJ, Horton E, Mechanick JI. Vitamin D in the Persian Gulf: Intergrative physiology and socioeconomic factors. Curr Osteoporos Rep 2011; 9: 243-250
    CrossrefPubMedGoogle Scholar
  • 4 Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, El-Kholie E, Yousef M, Al-Othman A, Al-Saleh Y, Sabico S, Kumar S, Chrousos GP. Increased Vitamin D Supplementation Recommended during Summer Season in the Gulf Region: A Counterintuitive Seasonal Effect in Vitamin D Levels in Adult, Overweight and Obese Middle-eastern Residents. Clin Endocrinol 2012; 76: 346-350
    CrossrefPubMedGoogle Scholar
  • 5 Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Al-Yousef M, Nadhrah H, Sabico S, Chrousos GP. Severe hypovitaminosis D is widespread in Saudi adults and is more common in non-diabetics than diabetics. Saudi Med J 2010; 31: 775-780
    PubMedGoogle Scholar
  • 6 Al-Sultan AI, Amin TT, Abou-Seif MA, Al Naboli MR. Vitamin D, parathyroid hormone levels and insulin sensitivity among obese and young adult Saudis. Eur Rev Med Pharmacol Sci 2011; 15: 135-147
    PubMedGoogle Scholar
  • 7 Hanley DA, Cranney A, Jones G, Whiting SJ, Leslie WD, Cole DE, Atkinson SA, Josse RG, Feldman S, Kline GA, Rosen C. Guidelines Committee of the Scientific Advisory Council of Osteoporosis Canada. Vitamin D in adult health and disease: a review and guideline statement from Osteoporosis Canada. CMAJ 2010; 182: E610-E618
    CrossrefPubMedGoogle Scholar
  • 8 Komaba H, Shiizaki K, Fukugawa M. Pharmacotherapy and interventional treatments for secondary hyperparathyroidism: current therapy and future challenges. Expert Opin Biol Ther 2010; 10: 1729-1742
    CrossrefPubMedGoogle Scholar
  • 9 Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000; 72: 690-693
    PubMedGoogle Scholar
  • 10 Ardawi MS, Sibiany AM, Bakhish TM, Qari MH, Maimani AA. High prevalence of vitamin D deficiency among healthy Saudi Arabian men: relationship to bone mineral density, parathyroid hormone, bone turnover markers and healthy factors. Osteoporos Int 2012; 23: 675-686
    CrossrefPubMedGoogle Scholar
  • 11 Ardawi MS, Qari MH, Rouzi AA, Maimani AA, Raddadi RM. Vitamin D status in relation to obesity, bone mineral density, bone turnover markers and vitamin D receptor genotypes in healthy Saudi pre- and postmenopausal women. Osteoporos Int 2011; 22: 463-475
    CrossrefPubMedGoogle Scholar
  • 12 Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Yousef M, Nadhrah HM, Al-Othman A, Al-Saleh Y, Sabico S, Chrousos GP. Hypovitaminosis D and cardiometabolic risk factors among non-obese youth. Cent Eur J Med 2010; 5: 752-757
    CrossrefPubMedGoogle Scholar
  • 13 Houghton LA, Szymlek-Gay EA, Gray AR, Ferguson EL, Deng X, Heath HL. Predictors of vitamin D status and its association with parathyroid hormone in young New Zealand children. Am J Clin Nutr 2010; 92: 69-76
    CrossrefPubMedGoogle Scholar
  • 14 Ginde AA, Wolfe P, Camargo Jr CA, Schwartz RS. Defining vitamin D status by secondary hyperparathyroidism in the US population. J Endocrinol Invest 2012; 35: 42-48
    PubMedGoogle Scholar
  • 15 Frost M, Abrahamsen B, Nielsen TL, Hagen C, Andersen M, Brixen K. Vitamin D status and PTH in young men: a cross-sectional study on associations with bone mineral density, body composition and glucose metabolism. Clin Endocrinol (Oxford) 2010; 73: 573-580
    CrossrefPubMedGoogle Scholar
  • 16 Schoenmakers I, Ginty F, Jarjou LM, Nigdikar S, Bennett J, Laidlaw A, Prentice A. Interrelation of parathyroid hormone and vitamin D metabolites in adolescents from the UK and Gambia. J Steroid Biochem Mol Biol 2010; 121: 217-220
    CrossrefPubMedGoogle Scholar
  • 17 Jabbar Z, Aggarawal PK, Chandel N, Kohli HS, Gupta KL, Sakhuja V, Jha V. High prevalence of vitamin D deficiency in north Indian adults is exacerbated in those with chronic kidney disease. Nephrology (Carlton) 2009; 14: 345-349
    CrossrefPubMedGoogle Scholar
  • 18 Kim JH, Moon SJ. Time spent outdoors and seasonal variation in serum concentrations of 25-hydroxyvitamin D in Korean women. Int J Food Sci Nutr 2000; 51: 439-451
    CrossrefPubMedGoogle Scholar
  • 19 Chan R, Chan D, Woo J, Ohlsson C, Mellstrom D, Kwok T, Leung P. Serum 25-hydroxyvitamin D and parathyroid hormone levels in relation to blood pressure in a cross-sectional study in older Chinese men. J Hum Hypertens 2012; 26: 20-27
    CrossrefPubMedGoogle Scholar
  • 20 Vanlint SJ, Morris HA, Newbury JW, Crocket AJ. Vitamin D insufficiency in Aboriginal Australians. Med J Aust 2011; 194: 131-134
    PubMedGoogle Scholar
  • 21 Kristal-Boneth E, Froom P, Harari G, Ribak J. Association of calcitriol and blood pressure in normotensive men. Hypertension 1997; 30: 1289-1294
    CrossrefPubMedGoogle Scholar
  • 22 Lind L, Hanni A, Lithell H, Hvarfner A, Sorensen OH, Ljunghall S. Vitamin D is related to blood pressure and other cardiovascular risk factors in middle-aged men. Am J Hypertens 1995; 8: 894-901
    CrossrefPubMedGoogle Scholar
  • 23 Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP. 1, 25 dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 2002; 110: 229-238
    CrossrefPubMedGoogle Scholar
  • 24 Judd SE, Raiser SN, Kumari M, Tangpricha V. 1,25-dihydroxyvitamin D3 reduces systolic blood pressure in hypertensive adults: a pilot feasibility study. J Steroid Biochem Mol Biol 2010; 121: 445-447
    CrossrefPubMedGoogle Scholar
  • 25 Alemzadeh R, Kichler J, Babar G, Calhoun M. Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity and season. Metabolism 2008; 57: 183-191
    Google Scholar
  • 26 Bickle DD, Gee E, Halloran B, Kowalski MA, Ryzen E, Haddad JG. Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. J Clin Endocrinol Metab 1986; 63: 954-959
    CrossrefPubMedGoogle Scholar