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Semin Thromb Hemost 2015; 41(03): 267-271
DOI: 10.1055/s-0035-1547372
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Rapid Evaluation of Fibrinogen Levels Using the CG02N Whole Blood Coagulation Analyzer

Mineji Hayakawa
1   Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, Japan
,
Satoshi Gando
1   Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, Japan
,
Yuichi Ono
1   Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, Japan
,
Asumi Mizugaki
1   Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, Japan
,
Kenichi Katabami
1   Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, Japan
,
Kunihiko Maekawa
1   Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, Japan
,
Daisuke Miyamoto
1   Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, Japan
,
Takeshi Wada
1   Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, Japan
,
Yuichiro Yanagida
1   Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, Japan
,
Atsushi Sawamura
1   Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, Japan
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Publikationsverlauf

Publikationsdatum:
03. April 2015 (online)

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Abstract

Rapid evaluation of fibrinogen (Fbg) levels is essential for maintaining homeostasis in patients with massive bleeding during severe trauma and major surgery. This study evaluated the accuracy of fibrinogen levels measured by the CG02N whole blood coagulation analyzer (A&T Corporation, Kanagawa, Japan) using heparinized blood drawn for blood gas analysis (whole blood-Fbg). A total of 100 matched pairs of heparinized blood samples and citrated blood samples were simultaneously collected from patients in the intensive care unit. Whole blood-Fbg results were compared with those of citrated plasma (standard-Fbg). The whole blood coagulation analyzer measured fibrinogen levels within 2 minutes. Strong correlations between standard-Fbg and whole blood-Fbg were observed (ρ = 0.91, p < 0.001). Error grid analysis showed that 88% of the values were clinically acceptable, and 12% were in a range with possible effects on clinical decision-making; none were in a clinically dangerous range without appropriate treatment. Using a fibrinogen cutoff value of 1.5 g/L for standard-Fbg, the area under the receiver operating characteristic curve of whole blood-Fbg was 0.980 (95% confidence interval 0.951–1.000, p < 0.001). The whole blood coagulation analyzer can rapidly measure fibrinogen levels in heparinized blood and could be useful in critical care settings where excessive bleeding is a concern.

Keywords

fibrinogen - point-of-care - coagulopathy - massive transfusion

Authorship

M. H. contributed to the study design, data acquisition, and interpretation, statistical analysis, and drafting of the article. S. G. contributed to data interpretation and drafting of the article. Y. O., A. M., K. K., K. M., D. M., T. W., Y. Y., and A. S. contributed to data acquisition and interpretation.


 

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