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Thromb Haemost 2003; 90(01): 147-154
DOI: 10.1055/s-0037-1613611
New Technologies and Diagnostic Tools
Schattauer GmbH

Course of indicators of thrombin activity in the early phase of acute myocardial infarction: effect of fibrinolytic therapy and acute percutaneous coronary angioplasty

Carl-Erik Dempfle
1   University Hospital of Mannheim, I. Department of Medicine, Mannheim, Germany
,
Jens J. Kaden
1   University Hospital of Mannheim, I. Department of Medicine, Mannheim, Germany
,
Karl K. Haase
1   University Hospital of Mannheim, I. Department of Medicine, Mannheim, Germany
,
Martin Borggrefe
1   University Hospital of Mannheim, I. Department of Medicine, Mannheim, Germany
› Author Affiliations
Further Information

Publication History

Received 14 February 2003

Accepted after revision 04 April 2003

Publication Date:
07 December 2017 (online)

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Summary

We evaluated assay systems for detection of in vivo thrombin activity in patients with acute myocardial infarction. The study included 31 consecutive patients with acute myocardial infarction treated either with fibrinolytic therapy (FLT), or acute PTCA. Blood samples were drawn at admission, after 30 min, 1 h, 3 h, 6 h, 12 h, 24, and 48 h. Assays related to the enzymatic action of thrombin included fibrinopeptide A ELISA, a novel latex-enhanced photometric immunoassay for soluble fibrin complexes, fibrin monomer antigen, D-dimer antigen, and soluble platelet glycoprotein V, which is released from the platelet surface by thrombin cleavage.

The soluble fibrin assay displayed a high degree of correlation with fibrinopeptide A, and no correlation with D-dimer antigen, indicating that this parameter allows monitoring of in vivo thrombin activity in patients with acute myocardial infarction. Fibrin monomer antigen, and D-dimer antigen, were influenced by FLT, indicating cross-reactivity with proteolytic fragments of fibrin. No significant changes in soluble glycoprotein V were observed.

The results show that the novel soluble fibrin assay appears to be a promising method for measurement of in vivo fibrin formation in patients with acute myocardial infarction, irrespective of the primary treatment decision for FLT or acute PTCA.

Keywords

Fibrinopeptide A - fibrin monomer - soluble fibrin - D-dimer - acute myocardial infarction
 

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