Thromb Haemost 1989; 61(03): 463-467
DOI: 10.1055/s-0038-1646615
Original Article
Schattauer GmbH Stuttgart

Involvement of 5-Hydroxytryptamine in Platelet Aggregation In Vivo in Rats and Guinea Pigs

G M Smith
The School of Pharmacy, Robert Gordon’s Institute of Technology, Aberdeen, Great Britain Key words
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Publikationsverlauf

Received 30. September 1988

Accepted after revision 30. Januar 1989

Publikationsdatum:
24. Juli 2018 (online)

Summary

In this study, 5-hydroxytryptamine (5-HT) caused a dose- dependent fall in the circulating platelet count suggesting that 5-HT receptors are activated in rat platelets to cause platelet adhesion and aggregation. When low doses of adenosine diphosphate (ADP) were simultaneously injected with 5-HT, there was a significant potentiation of the responses to ADR Ketanserin significantly reduced the potentiated responses. When higher doses of ADP were infused with bolus injections of 5-HT there was no potentiation and ketanserin did not reduce these responses. Ketanserin did not inhibit the collagen-induced fall in circulating platelet count, but did significantly increase the rate of return to the basal platelet count compared with control. 5-HT did not cause a fall in platelet count in guinea-pigs

 
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