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Thromb Haemost 1986; 56(03): 263-267
DOI: 10.1055/s-0038-1661663
Original Article
Schattauer GmbH Stuttgart

The Effects of Modulation of Prostanoid Metabolism on the Thoracic Platelet Accumulation Induced by Intravenous Administration of Collagen in the Guinea-Pig

K D Butler
The Research Centre, CIBA-GEIGY Pharmaceuticals, Horsham, West Sussex, UK
,
R A Shand
The Research Centre, CIBA-GEIGY Pharmaceuticals, Horsham, West Sussex, UK
,
R B Wallis
The Research Centre, CIBA-GEIGY Pharmaceuticals, Horsham, West Sussex, UK
› Author Affiliations
Further Information

Publication History

Received 20 March 1986

Accepted after revision 19 August 1986

Publication Date:
18 July 2018 (online)

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Summary

The effects of intravenously administered collagen on the circulatory platelet count, TxB2, 6-keto PGF1α and 51Cr-labelled platelet accumulation in the thorax have been evaluated in the guinea-pig. Administration of collagen induced a dose-related peripheral thrombocytopenia and a concomitant increase in 51Cr-labelled platelets in the thorax. There was also a transient dose-related increase in plasma TxB2 but no change in plasma 6-keto PGF1α levels.

The thromboxane synthetase inhibitors tested, reduced the platelet accumulation, but only CGS 13080 significantly inhibited TxB2 production. In contrast all the cyclooxygenase inhibitors tested impaired the elevation of plasma TxB2 after collagen, but only diclofenac inhibited the 51Cr-labelled platelet accumulation.

The greater effect of thromboxane synthetase inhibitors compared to cyclooxygenase inhibitors on platelet accumulation in this system cannot be completely explained by the changes measured in the circulating prostanoids.

Key words

Collagen - Cyclooxygenase inhibition - Thromboxane synthetase inhibitors - Platelet aggregation in vivo
 

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