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Horm Metab Res 2003; 35(6): 377-381
DOI: 10.1055/s-2003-41361
Original Clinical
© Georg Thieme Verlag Stuttgart · New York

High Serum Circulating Telopeptide Type I in Multinodular Goiter

A.  Loviselli1 , E.  Rizzolo1 , R.  Mastinu1 , F.  Velluzzi1 , G.  Secci1 , A.  Taberlet1 , S.  Mariotti1
  • 1Endocrinology, Department of Medical Sciences, University of Cagliari, Italy
Further Information

Publication History

Received 22 August 2002

Accepted after Revision 19 December 2002

Publication Date:
15 August 2003 (online)

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Abstract

Recently, concentrations of serum carboxy-terminal-1-telopeptide (ICTP), a marker of bone collagen resorption, were found to be more sensitive than sex hormone-binding globulin (SHBG) in identifying peripheral overexposure to thyroid hormones in exogenous subclinical hyperthyroidism. The aim of the present study was to assess serum ICTP and SHBG in multinodular goiter with (pretoxic goiter) or without biochemical evidence of endogenous subclinical hyperthyroidism. Forty-five women affected by multinodular goiter were enrolled in this study. They were subdivided into two groups: group 1, consisting of 27 patients affected by pretoxic goiter; group 2, consisting of 18 patients affected by non toxic goiter; group 3, consisting of thirty-six euthyroid women matched with the other groups for age and lifestyle. In group 1, serum ICTP (mean ± SD: 5.8 ± 2.9 µg/l) concentrations were significantly higher when compared either to group 2 (3.6 ± 1.2 µg/l; p < 0.02) or controls (2.7 ± 0.7 µg/l; p < 0.0001); serum ICTP concentrations were also slightly but significantly higher in patients of group 2 compared to controls (p < 0.003). In contrast, mean serum SHBG concentrations did not show any difference among the three groups. No significant correlation was found between serum TSH and ICTP concentrations, while a weak positive correlation (p < 0.05) was only found between serum FT3 and ICTP concentrations when data from the two patient groups were analyzed together. Moreover, when we subdivided patients into pre- and postmenopausal patients, we observed that SHBG but not ICTP serum concentrations were influenced by estrogenic status. In summary, the measurement of serum ICTP seems to be more suitable than SHBG for identifying those with a higher degree of peripheral thyroid hormone exposure in women affected by endogenous subclinical hyperthyroidism.

Key words

Subclinical Hyperthyroidism - Nodular Goiter - Telopeptide

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Prof. A. Loviselli, M. D.

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Fax: + 39 (70) 60285-221

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