Functional and Diffusion-Weighted Magnetic Resonance Imaging for Visualization of the Postthalamic Visual Fiber Tracts and the Visual Cortex

Abstract

Diffusion-weighted magnetic resonance imaging (MRI) offers the possibility to study the course of the cerebral white matter tracts whereas functional MRI (fMRI) provides information about the specific functions of cortical areas. We evaluated the combination of fMRI and diffusion-weighted MRI to detect cortical visual areas with their corresponding visual fiber tracts in 15 healthy controls (age: 23 - 53 years, male : female = 8 : 7). We demonstrated activation within the primary visual cortex and white matter bundles connecting the lateral geniculate body and the striate cortex in all subjects investigated. Additional activation could be appreciated in some subjects within the lateral geniculate bodies (n = 2) and the motion-sensitive area V5 (n = 3). The combination of diffusion-weighted and functional imaging allows visualization of the origin, direction and functionality of large white matter tracts. This will prove helpful for imaging structural connectivity within the brain during functional imaging. Moreover, this technique might provide important information for neurosurgical patients presenting with space-occupying lesions close to the cortical and subcortical visual system since this technique can - in contrast to diffusion tensor imaging - easily be adopted into a neuronavigation system and can be performed on all MR scanners capable of diffusion-weighted imaging without specific post-processing programs.

Key words

Diffusion weighted MRI - functional MRI - neuronavigation - visual system

References

• 1 Basser P J, Mattiello J, Le Bihan D. Estimation of the effective self-diffusion tensor from the NMR spin echo.  J Magn Reson. 1994;  103 247-254
• 2 Basser P J, Pajevic S, Pierpaoli C, Duda J, Aldroubi A. In vivo fiber tractography using DT-MRI data.  Magn Reson Med. 2000;  44 625-632
• 3 Basser P J, Pierpaoli C. Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRL.  J Magn Reson B. 1996;  111 209-219
• 4 Beaulieu C, Allen P S. Determinants of anisotropic water diffusion in nerves.  Magn Reson Med. 1994;  31 394-400
• 5 Beaulieu C, Allen P S. Water diffusion in the giant axon of the squid: implications for diffusion-weighted MRI of the nervous system.  Magn Reson Med. 1994;  32 579-583
• 6 Beaulieu C. The basis of anisotropic water diffusion in the nervous system - a technical review.  NMR Biomed. 2002;  15 435-455
• 7 Büchel C, Coull J T, Friston K. The predictive value of changes in effective connectivity for human learning.  Science. 1999;  283 1538-1541
• 8 Coenen V A, Krings T, Mayfrank L, Polin R S, Reinges M H, Thron A, Gilsbach J M. Three-dimensional visualization of the pyramidal tract in a neuronavigation system during brain tumor surgery: first experiences and technical note.  Neurosurgery. 2001;  49 86-93
• 9 Doran M, Hajnal J V, Van Bruggen N, King M D, Young I R, Bydder G M. Normal and abnormal white matter tracts shown by MR imaging using directional diffusion weighted sequences.  J Comput Assist Tomogr. 1990;  14 865-873
• 10 Douek P, Turner R, Pekar J, Patronas N, Le Bihan D. MR color mapping of myelin fiber orientation.  J Comput Assist Tomogr. 1991;  15 923-929
• 11 Ebeling U, Reulen H J. Neurosurgical topography of the optic radiation in the temporal lobe.  Acta Neurochir (Wien). 1988;  92 29-36
• 12 Krings T, Coenen V A, Axer H, Reinges M H, Holler M, Keyserlingk D G von, Gilsbach J M, Thron A. In vivo 3D visualization of normal pyramidal tracts in human subjects using diffusion weighted magnetic resonance imaging and a neuronavigation system.  Neurosci Lett. 2001;  307 192-196
• 13 Krings T, Reinges M H, Thiex R, Gilsbach J M, Thron A. Functional and diffusion-weighted magnetic resonance images of space-occupying lesions affecting the motor system: imaging the motor cortex and pyramidal tracts.  J Neurosurg. 2001;  95 816-824
• 14 Krings T, Topper R, FoItys H, Erberich S, Sparing R, Willmes K, Thron A. Cortical activation patterns during complex motor tasks in piano players and control subjects. A functional magnetic resonance imaging study.  Neurosci Lett. 2000;  278 189-193
• 15 Makris N, Worth A J, Sorensen A G, Papadimitriou G M, Wu O, Reese T G, Wedeen V J, Davis T L, Stakes J W, Caviness V S, Kaplan E, Rosen B R, Pandya D N, Kennedy D N. Morphometry of in vivo human white matter association pathways with diffusion-weighted magnetic resonance imaging.  Ann Neurol. 1997;  42 951-962
• 16 Melhem E R, Mori S, Mukundan G, Kraut M A, Pomper M G, Zijl P C van. Diffusion tensor MR imaging of the brain and white matter tractography.  AJR Am J Roentgenol. 2002;  178 3-16
• 17 Pierpaoli C, Jezzard P, Basser P J, Barnett A, Di Chiro G. Diffusion tensor MR imaging of the human brain.  Radiology. 1996;  201 637-648
• 18 Werring D J, Clark C A, Parker G JM, Miller D H, Thompson A J, Barker G J. A direct demonstration of both structure and function in the visual system: combining diffusion tensor imaging with functional magnetic resonance imaging.  Neurolmage. 1999;  9 352-361
• 19 Wieshmann U C, Symms M R, Parker G J, Clark C A, Lemieux L, Barker G J, Shorvon S D. Diffusion tensor imaging demonstrates deviation of fibres in normal appearing white matter adjacent to a brain tumour.  J Neurol Neurosurg Psychiatry. 2000;  68 501-503
• 20 Wildgruber D, Erb M, Klose D, Grodd W. Sequential activation of supplementary motor area and primary motor cortex during self-paced finger movement in human evaluated by functional MRI.  Neurosci Lett. 1997;  227 161-164