Clin Colon Rectal Surg 2005; 18(3): 232-243
DOI: 10.1055/s-2005-916284
Copyright © 2005 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Follow-Up Recommendations for Colon Cancer

W. Donald Buie1 , 2 , Jo-Anne P. Attard1
  • 1Department of Surgery, University of Calgary, Calgary, Alberta, Canada
  • 2Department of Oncology, University of Calgary, Calgary, Alberta, Canada
Further Information

Publication History

Publication Date:
02 September 2005 (online)

ABSTRACT

Recent evidence suggests that intensive follow-up after curative resection of colorectal cancer is associated with a small but significant improvement in survival. Regimens that employ cross-sectional imaging and carcinoembryonic antigen determination appear to have the greatest benefit. A risk-adapted approach to follow-up, intensively following patients at highest risk of recurrence, increases efficacy and cost-effectiveness. Ongoing improvements in risk stratification, disease detection, and treatment will increase the benefits of postoperative surveillance. Large randomized controlled trials are needed to determine the optimal surveillance regimen and must include an analysis of survival, quality of life, and cost-effectiveness to assess efficacy properly.

REFERENCES

  • 1 Bohm B, Schwenk W, Hucke H P et al.. Does methodic long-term follow-up affect survival after curative resection of colorectal carcinoma?.  Dis Colon Rectum. 1993;  36 280-286
  • 2 Falterman K W, Hill C B, Markey J C et al.. Cancer of the colon, rectum, and anus: a review of 2313 cases.  Cancer. 1974;  34:suppl 951-9
  • 3 Moertel C G, Fleming T R, Macdonald J S et al.. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma.  N Engl J Med. 1990;  322 352-358
  • 4 Olson R M, Perencevich N P, Malcolm A W et al.. Patterns of recurrence following curative resection of adenocarcinoma of the colon and rectum.  Cancer. 1980;  45 2969-2974
  • 5 Pestana C, Reitemeier R J, Moertel C G et al.. The natural history of carcinoma of the colon and rectum.  Am J Surg. 1964;  108 826-829
  • 6 Safi F, Beyer H G. The value of follow-up after curative surgery of colorectal carcinoma.  Cancer Detect Prev. 1993;  17 417-424
  • 7 Goldberg R M, Fleming T R, Tangen C M et al.. Surgery for recurrent colon cancer: strategies for identifying resectable recurrence and success rates after resection. Eastern Cooperative Oncology Group, the North Central Cancer Treatment Group, and the Southwest Oncology Group.  Ann Intern Med. 1998;  129 27-35
  • 8 Scholefield J H, Steele R J. Guidelines for follow up after resection of colorectal cancer.  Gut. 2002;  51(suppl 5) V3-V5
  • 9 Ohlsson B, Breland U, Ekberg H et al.. Follow-up after curative surgery for colorectal carcinoma. Randomized comparison with no follow-up.  Dis Colon Rectum. 1995;  38 619-626
  • 10 Deveney K E, Way L W. Follow-up of patients with colorectal cancer.  Am J Surg. 1984;  148 717-722
  • 11 Sugarbaker P H, Gianola F J, Dwyer A et al.. A simplified plan for follow-up of patients with colon and rectal cancer supported by prospective studies of laboratory and radiologic test results.  Surgery. 1987;  102 79-87
  • 12 Meyerhardt J A, Mayer R J. Follow-up strategies after curative resection of colorectal cancer.  Semin Oncol. 2003;  30 349-360
  • 13 Hughes K S, Simon R, Songhorabodi S et al.. Resection of the liver for colorectal carcinoma metastases: a multi-institutional study of patterns of recurrence.  Surgery. 1986;  100 278-284
  • 14 Ballantyne G H, Quin J. Surgical treatment of liver metastases in patients with colorectal cancer.  Cancer. 1993;  71 4252-4266
  • 15 McAfee M K, Allen M S, Trastek V F et al.. Colorectal lung metastases: results of surgical excision.  Ann Thorac Surg. 1992;  53 780-785
  • 16 Fong Y, Cohen A M, Fortner J G et al.. Liver resection for colorectal metastases.  J Clin Oncol. 1997;  15 938-946
  • 17 Steele Jr G. Standard postoperative monitoring of patients after primary resection of colon and rectum cancer.  Cancer. 1993;  71 4225-4235
  • 18 Pietra N, Sarli L, Costi R et al.. Role of follow-up in management of local recurrences of colorectal cancer: a prospective, randomized study.  Dis Colon Rectum. 1998;  41 1127-1133
  • 19 Secco G B, Fardelli R, Gianquinto D et al.. Efficacy and cost of risk-adapted follow-up in patients after colorectal cancer surgery: a prospective, randomized and controlled trial.  Eur J Surg Oncol. 2002;  28 418-423
  • 20 Renehan A G, Egger M, Saunders M P et al.. Impact on survival of intensive follow up after curative resection for colorectal cancer: systematic review and meta-analysis of randomised trials.  BMJ. 2002;  324 813
  • 21 Jeffery G M, Hickey B E, Hider P. Follow-up strategies for patients treated for non-metastatic colorectal cancer.  Cochrane Database Syst Rev. 2002;  , 1. art. no. CD002200 DOI 10.1002/14651858-1-26
  • 22 Tornqvist A, Ekelund G, Leandoer L. Early diagnosis of metachronous colorectal carcinoma.  Aust N Z J Surg. 1981;  51 442-445
  • 23 Heald R J, Lockhart-Mummery H E. The lesion of the second cancer of the large bowel.  Br J Surg. 1972;  59 16-19
  • 24 McArdle C. ABC of colorectal cancer: effectiveness of follow up.  BMJ. 2000;  321 1332-1335
  • 25 Anthony T, Simmang C, Hyman N et al.. Practice parameters for the surveillance and follow-up of patients with colon and rectal cancer.  Dis Colon Rectum. 2004;  47 807-817
  • 26 Stiggelbout A M, de Haes J C, Vree R et al.. Follow-up of colorectal cancer patients: quality of life and attitudes towards follow-up.  Br J Cancer. 1997;  75 914-920
  • 27 Kiebert G M, Welvaart K, Kievit J. Psychological effects of routine follow up on cancer patients after surgery.  Eur J Surg. 1993;  159 601-607
  • 28 Kjeldsen B J, Thorsen H, Whalley D et al.. Influence of follow-up on health-related quality of life after radical surgery for colorectal cancer.  Scand J Gastroenterol. 1999;  34 509-515
  • 29 Hennekens C, Buring J. Epidemiology in Medicine. Philadelphia; Lippincott Williams & Wilkins 1987: 327-347
  • 30 Phillips R K, Hittinger R, Blesovsky L et al.. Large bowel cancer: surgical pathology and its relationship to survival.  Br J Surg. 1984;  71 604-610
  • 31 Finlay I G, McArdle C S. Occult hepatic metastases in colorectal carcinoma.  Br J Surg. 1986;  73 732-735
  • 32 Figueredo A, Rumble R B, Maroun J et al.. Follow-up of patients with curatively resected colorectal cancer: a practice guideline.  BMC Cancer. 2003;  3 26
  • 33 Gordis L. Epidemiology. 2nd ed. Philadelphia; WB Saunders 2000: 60-70
  • 34 Wein A, Riedel C, Bruckl W et al.. Neoadjuvant treatment with weekly high-dose 5-fluorouracil as 24-hour infusion, folinic acid and oxaliplatin in patients with primary resectable liver metastases of colorectal cancer.  Oncology. 2003;  64 131-138
  • 35 Pozzo C, Basso M, Cassano A et al.. Neoadjuvant treatment of unresectable liver disease with irinotecan and 5-fluorouracil plus folinic acid in colorectal cancer patients.  Ann Oncol. 2004;  15 933-939
  • 36 Johnson F E, Virgo K S, Fossati R. Follow-up for patients with colorectal cancer after curative-intent primary treatment.  J Clin Oncol. 2004;  22 1363-1365
  • 37 Vernava III A M, Longo W E, Virgo K S et al.. Current follow-up strategies after resection of colon cancer. Results of a survey of members of the American Society of Colon and Rectal Surgeons.  Dis Colon Rectum. 1994;  37 573-583
  • 38 Kjeldsen B J, Kronborg O, Fenger C et al.. A prospective randomized study of follow-up after radical surgery for colorectal cancer.  Br J Surg. 1997;  84 666-669
  • 39 Mäkelä J T, Laitinen S O, Kairaluoma M I. Five-year follow-up after radical surgery for colorectal cancer. Results of a prospective randomized trial.  Arch Surg. 1995;  130 1062-1067
  • 40 Schoemaker D, Black R, Giles L et al.. Yearly colonoscopy, liver CT, and chest radiography do not influence 5-year survival of colorectal cancer patients.  Gastroenterology. 1998;  114 7-14
  • 41 Staib L, Link K H, Beger H G. Follow-up in colorectal cancer: cost-effectiveness analysis of established and novel concepts.  Langenbecks Arch Surg. 2000;  385 412-420
  • 42 Desch C E, Benson III A B, Smith T J et al.. Recommended colorectal cancer surveillance guidelines by the American Society of Clinical Oncology.  J Clin Oncol. 1999;  17 1312
  • 43 Fleischer D E, Goldberg S B, Browning T H et al.. Detection and surveillance of colorectal cancer.  JAMA. 1989;  261 580-585
  • 44 Engstrom P F, Benson III A B, Cohen A et al.. NCCN Colorectal Cancer Practice Guidelines. The National Comprehensive Cancer Network.  Oncology (Williston Park). 1996;  10(11 suppl) 140-175
  • 45 Practice NCCN .Guidelines in Oncology-v2. 2005 Colon Cancer http://www.nccn.org/professionals/physicians_gls/PDF/colon.pdf
  • 46 Fantini G A, DeCosse J J. Surveillance strategies after resection of carcinoma of the colon and rectum.  Surg Gynecol Obstet. 1990;  171 267-273
  • 47 Galandiuk S, Wieand H S, Moertel C G et al.. Patterns of recurrence after curative resection of carcinoma of the colon and rectum.  Surg Gynecol Obstet. 1992;  174 27-32
  • 48 Mäkelä J, Haukipuro K, Laitinen S et al.. Surgical treatment of recurrent colorectal cancer. Five-year follow-up.  Arch Surg. 1989;  124 1029-1032
  • 49 Ovaska J, Jarvinen H, Kujari H et al.. Follow-up of patients operated on for colorectal carcinoma.  Am J Surg. 1990;  159 593-596
  • 50 Tornqvist A, Ekelund G, Leandoer L. The value of intensive follow-up after curative resection for colorectal carcinoma.  Br J Surg. 1982;  69 725-728
  • 51 Richard C S, McLeod R S. Follow-up of patients after resection for colorectal cancer: a position paper of the Canadian Society of Surgical Oncology and the Canadian Society of Colon and Rectal Surgeons.  Can J Surg. 1997;  40 90-100
  • 52 Graffner H, Hultberg B, Johansson B et al.. Detection of recurrent cancer of the colon and rectum.  J Surg Oncol. 1985;  28 156-159
  • 53 Graham R A, Wang S, Catalano P J et al.. Postsurgical surveillance of colon cancer: preliminary cost analysis of physician examination, carcinoembryonic antigen testing, chest x-ray, and colonoscopy.  Ann Surg. 1998;  228 59-63
  • 54 McCall J L, Black R B, Rich C A et al.. The value of serum carcinoembryonic antigen in predicting recurrent disease following curative resection of colorectal cancer.  Dis Colon Rectum. 1994;  37 875-881
  • 55 Moertel C G, Fleming T R, Macdonald J S et al.. An evaluation of the carcinoembryonic antigen (CEA) test for monitoring patients with resected colon cancer.  JAMA. 1993;  270 943-947
  • 56 Fletcher R H. Carcinoembryonic antigen.  Ann Intern Med. 1986;  104 66-73
  • 57 Goslin R, Steele Jr G, Macintyre J et al.. The use of preoperative plasma CEA levels for the stratification of patients after curative resection of colorectal cancers.  Ann Surg. 1980;  192 747-751
  • 58 Fucini C, Tommasi S M, Rosi S et al.. Follow-up of colorectal cancer resected for cure. An experience with CEA, TPA, Ca 19-9 analysis and second-look surgery.  Dis Colon Rectum. 1987;  30 273-277
  • 59 Martin Jr E W, Cooperman M, Carey L C et al.. Sixty second-look procedures indicated primarily by rise in serial carcinoembryonic antigen.  J Surg Res. 1980;  28 389-394
  • 60 Goya T, Miyazawa N, Kondo H et al.. Surgical resection of pulmonary metastases from colorectal cancer. 10-year follow-up.  Cancer. 1989;  64 1418-1421
  • 61 McCormack P M, Attiyeh F F. Resected pulmonary metastases from colorectal cancer.  Dis Colon Rectum. 1979;  22 553-556
  • 62 Smith T J, Bear H D. Standard follow-up of colorectal cancer patients: finally, we can make practice guidelines based on evidence.  Gastroenterology. 1998;  114 211-213
  • 63 Chau I, Allen M J, Cunningham D et al.. The value of routine serum carcino-embryonic antigen measurement and computed tomography in the surveillance of patients after adjuvant chemotherapy for colorectal cancer.  J Clin Oncol. 2004;  22 1420-1429
  • 64 Adam R, Avisar E, Ariche A et al.. Five-year survival following hepatic resection after neoadjuvant therapy for nonresectable colorectal.  Ann Surg Oncol. 2001;  8 347-353
  • 65 Giacchetti S, Itzhaki M, Gruia G et al.. Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery.  Ann Oncol. 1999;  10 663-669
  • 66 Winawer S, Fletcher R, Rex D et al.. Colorectal cancer screening and surveillance: clinical guidelines and rationale-update based on new evidence.  Gastroenterology. 2003;  124 544-560
  • 67 Anthony T, Fleming J B, Bieligk S C et al.. Postoperative colorectal cancer surveillance.  J Am Coll Surg. 2000;  190 737-749
  • 68 Cali R L, Pitsch R M, Thorson A G et al.. Cumulative incidence of metachronous colorectal cancer.  Dis Colon Rectum. 1993;  36 388-393
  • 69 Green R J, Metlay J P, Propert K et al.. Surveillance for second primary colorectal cancer after adjuvant chemotherapy: an analysis of Intergroup 0089.  Ann Intern Med. 2002;  136 261-269
  • 70 Winawer S J, Zauber A G, Ho M N et al.. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup.  N Engl J Med. 1993;  329 1977-1981
  • 71 Norum J, Olsen J A. A cost-effectiveness approach to the Norwegian follow-up programme in colorectal cancer.  Ann Oncol. 1997;  8 1081-1087
  • 72 Liberati A, Torri V, Apolone G. Assessing the effectiveness of follow-up care for colorectal cancer: a great conceptual and methodological challenge for clinical oncology.  Ann Oncol. 1997;  8 1059-1062
  • 73 Borie F, Combescure C, Daures J P et al.. Cost-effectiveness of two follow-up strategies for curative resection of colorectal cancer: comparative study using a Markov model.  World J Surg. 2004;  28 563-569
  • 74 Virgo K S, Vernava A M, Longo W E et al.. Cost of patient follow-up after potentially curative colorectal cancer treatment.  JAMA. 1995;  273 1837-1841
  • 75 Bruinvels D J, Stiggelbout A M, Kievit J et al.. Follow-up of patients with colorectal cancer. A meta-analysis.  Ann Surg. 1994;  219 174-182
  • 76 Renehan A G, O'Dwyer S T, Whynes D K. Cost effectiveness analysis of intensive versus conventional follow up after curative resection for colorectal cancer.  BMJ. 2004;  328 81
  • 77 Kraemer M, Wiratkapun S, Seow-Choen F et al.. Stratifying risk factors for follow-up: a comparison of recurrent and nonrecurrent colorectal cancer.  Dis Colon Rectum. 2001;  44 815-821
  • 78 ESMO .Minimum Clinical Recommendations. 2002 http://www.esmo.org/reference/reference_guidelines.htm

W. Donald BuieM.D. 

Foothills Hospital/SSB Rm. AC144D

1403 29th St., NW, Calgary, AB T2N 2T9 Canada

Email: wdbuie@ucalgary.ca

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