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Horm Metab Res 1993; 25(10): 528-531
DOI: 10.1055/s-2007-1002167
DOI: 10.1055/s-2007-1002167
Originals Basic
© Georg Thieme Verlag, Stuttgart · New York
Long-Term Exposure to SMS 201-995 Inhibits Proliferation and Calcitonin Release in Neoplastic C-Cells
Weitere Informationen
Publikationsverlauf
1992
1993
Publikationsdatum:
14. März 2008 (online)
Summary
The effect of the long-acting somatostatin analogue SMS 201-995 on cellular proliferation and calcitonin production was examined in rMTC 6-23 cells. A dose-dependent inhibition of calcitonin release and cellular calcitonin content was obtained in cells exposed to SMS 201-995 for 72 hrs. The dose-dependent antiproliferative effect of SMS 201-995 (10-8-10-6M) was significant after 72 hrs of exposure. SMS 201-995 has an inhibitory effect on calcitonin secretion and synthesis as well as on the growth of C-cells.
Key words
SMS 201-995 (Octreot) - Calcitonin - Secretion and Content - C-Cell Line (rMTC 6-23) - Medullary Thyroid Carcinoma (MTC)