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Horm Metab Res 1987; 19(2): 68-70
DOI: 10.1055/s-2007-1011741
Clinical

© Georg Thieme Verlag, Stuttgart · New York

The Effect of Enkephalin Analogue on Pituitary Hormone Release in Human Obesity

N. Finer1 , P. Price2 , A. Grossman2 , G. M. Besser2
  • 1Department of Medicine, Guy's Hospital Medical School, London, England
  • 2Department of Endocrinology, The Medical College of St. Bartholomew's Hospital, London, England
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Publikationsverlauf

1985

1986

Publikationsdatum:
14. März 2008 (online)

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Summary

To elucidate further the role of opioid systems in the neuroendocrine alterations associated with obesity, we investigated the effect of the synthetic enkephalin analogue DAMME in 11 obese subjects and 10 lean controls. Prolactin responses to DAMME were similar in lean and obese, even in those obese subjects who had absent prolactin responses to insulin-induced hypoglycaemia. The obese showed impaired growth hormone release after both DAMME and insulin-induced hypoglycaemia compared to the lean subjects. The discordance of prolactin responses to DAMME and insulin-induced hypoglycaemia in the obese suggests that altered opioid systems are unlikely to account for the hypothalamic dysfunction present in obesity.

Key-Words

Obesity - Prolactin - Growth Hormone - Hypothalamus - Enkephalin

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