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Horm Metab Res 1986; 18(6): 365-368
DOI: 10.1055/s-2007-1012318
ORIGINALS

© Georg Thieme Verlag, Stuttgart · New York

Effect of βh-Endorphin on Release of Insulin by Rabbit Pancreas in Response to Four Secretagogues: Comparison with Somatostatin and Epinephrine

D. Rudman, M. H. Kutner
  • Department of Medicine, University of Health Sciences, The Chicago Medical School, North Chicago, Illinois, and Department of Biometry, Emory University School of Medicine, Atlanta, Georgia, U.S.A.
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Publikationsverlauf

1984

1985

Publikationsdatum:
14. März 2008 (online)

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Summary

Previous work showed βh-endorphin inhibits glucose-stimulated secretion of insulin by rabbit pancreas slices. This study, also conducted with rabbit pancreas slices, compared the antisecretagogue actions of βh-endorphin, somatostatin 1-14, and epinephrine versus four secretagogues, glucose, mannose, leucine and potassium chloride. All three antisecretagogues inhibited all four secretagogues. The order of potency of the antisecretagogues varied according to secretagogue. Naloxone antiagonized only βh-endorphin among the three antisecretagogues, and phentolamine antagonized only epinephrine.

Key-Words

βh-Endorphin - Insulin Release - Rabbit Pancreas

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