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Horm Metab Res 1984; 16(12): 638-640
DOI: 10.1055/s-2007-1014871
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© Georg Thieme Verlag, Stuttgart · New York

Effect of a Single Dose of Triiodothyronine on the Uptake of (Methyl-14C) Choline into Chick Liver Phospholipids

A. Marino, J. R. Fedriani, M. J. Sancho, J. M. Macarulla
  • Department of Biochemistry, Faculty of Science, University of the Basque Country, Bilbao, Spain
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Publication History

1982

1983

Publication Date:
14 March 2008 (online)

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Summary

The effects of a single dose of 3,3′-5-triiodothyronine (T3) on the uptake of (methyl-14C) choline into liver phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) were studied in chicks as a function of time up to 6 h after injection of the radioactive precursor. In all cases, chicks received the T3 dose intraperitoneally 5 h before injection of the labelled compound.

T3 enhances the incorporation of 14C-choline into liver PC, showing a biphasic response; the main uptake occurs between 2 and 3 h after administering the precursor. A smaller but significant hormone-dependent increase in incorporation of the labelled compound is observed in the case of LPC. Lipid P associated to PC and LPC remains constant throughout the experiment, and does not vary with hormone treatment. It is suggested that T3-injection increases, either directly or through other metabolic processes, PC and LPC turnover in chick liver cells.

Key-Words:

Phospholipid Metabolism - Chick Metabolism - Triiodothyronine - Phosphatidylcholine - Lysophosphatidylcholine

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