PDF herunterladen
Horm Metab Res 1984; 16(12): 646-649
DOI: 10.1055/s-2007-1014873
Basic

© Georg Thieme Verlag, Stuttgart · New York

Sex Differences in Adrenocortical Structure and Function. XIV. Heparin-Releasable Liver-Lipase Like Activity in Rat Adrenals as Affected by Gonadectomy and Testosterone or Estradiol Replacement

L. K. Malendowicz1 , J. Paluszak2
  • 1Department of Histology and Embryology, Poznań Academy of Medicine, Poznań, Poland
  • 2Department of Physiology, Poznań Academy of Medicine, Poznań, Poland
Weitere Informationen

Publikationsverlauf

1983

1983

Publikationsdatum:
14. März 2008 (online)

Auch verfügbar auf
  als PDF herunterladen  Lizenzen und Reprints

Summary

Heparin-releasable liver-lipase like activity was studied in adrenals of intact, gonadectomized and gonadectomized-testosterone or estradiol replaced rats.

Besides acid lipase, rat adrenals contain a neutral lipase activity. From both male and female adrenals about 70% of this activity is extractable by heparin containing medium. Activity of this lipase in 8000 g supernatant was higher in female than male adrenals. Orchiectomy of 12 weeks duration increased neutral lipase activity in rat adrenal, an effect reversed to normal level by testosterone replacement. On the other hand ovariectomy had no effect while estradiol replacement resulted in an increased activity of the neutral lipase of rat adrenal gland.

The results showed a distinct sex-difference in heparin-releasable liver-lipase like activity of rat adrenals which depends on the inhibitory action of testosterone on the enzyme activity.

Key-Words:

Rat Adrenal Neutral Lipase Activity - Sex Differences - Gonadectomy - Gonadal Hormone Replacement

      >